ARTICLE OF THE MONTH Prospective Multi-Institutional Study of Eculizumab to Treat High-Risk Stem Cell Transplant Associated TMA.Jodele, S., et al. (2023) Blood [record in progress]PICO SUMMARY +++++ |
22 December 2023 (Friday) - Stem Cell Evidence Alert
The Stem Cell Evidence Alert update
arrived in my in-box today. There was quite a bit of talk about allogenic stem
cell transplants. Back in the day we used to do quite a few of those… but they
don’t seem to be anywhere near as common these days.
Perhaps it is a “specialist centre”
thing and not something done is the district general hospitals any more?
21 December 2023 (Thursday) - Swearing at the BTLP-TACT
Time for a BTLP-TACT exercise… I had two
cases:
79396 – A thirty-eight year-old chap in the haematology clinic requiring eight units of blood for an exchange transfusion (do they still happen?) for sickle cell diseaseHe grouped as A Rh(D) Positive with a weak D. With absolutely no idea what the “less than perfect(!)” software was expecting I called it indeterminate. But this is crap isn’t it (to be blunt). Given a patient in the haematology clinic known to have sickle cell disease requiring exchange transfusion, how likely is it that this dubious D group wouldn’t have been encountered and investigated years ago?The antibody screen was negative, for which I was grateful.I selected eight units of A Rh(D) Negative blood knowing full well the software wouldn’t be happy.16094 – A thirty-three year-old woman needing four units of blood for surgery.She too was a pain in the glass (as my grandson would say). An indeterminate ABO group but was Rh (D) Negative, and a positive antibody screen (in cells 1 & 2). I selected panels…The IAT and enzyme panels were positive in cells 1, 2. 3. and 5 corresponding with anti-D and anti-E but not excluding anti-CwI selected four units of O Rh(D) Negative which were also E and Cw negative
Needless to say I got the thumbs down. I’m
not quite sure why though. Apparently I got the group bits right but selected the
wrong blood components. But why I’d done that… It wouldn’t tell me. It has to
be said that as a learning tool the blood transfusion simulator leaves a lot to
be desired in that it seems to work in a way which is at odds to reality, and
when you get it wrong it won’t tell you why.
19 December 2023 (Tuesday) - Transfusion Evidence Alert Update
PCC or FFP? And tranexamic acid yet again!!! The regular
update from the nice people at the Transfusion Evidence Alert is always worth
having.
ARTICLE OF THE MONTH Restrictive or liberal transfusion strategy in myocardial infarction and anemia. +++++ |
13 December 2023 (Thursday) - HCPC Update
The HCPC sent their update today. You
can read it by
clicking here. I read it as I rather feel obliged to do so, and in all
honesty didn’t find anything I felt was relevant to me… but this left me rather
thoughtful. Bearing in mind it is a professionally produced document, either
the person being paid to produce it is the wrong person, or I’m missing the
point entirely.
I wonder which it is. I suspect the
latter.
12 December 2023 (Tuesday) - BTLP-TACT Exercise
I thought I’d try another BTLP-TACT exercise…
I had one case – an eighty-four year-old
chap in A&E requiring group & save. He grouped as O Rh(D) Positive with
a negative antibody screen
I got the green light… Bearing in mind the
debacle of last time I took screen shots every step of the way today. I can
delete them all now.
12 December 2023 (Tuesday) - Westgard QC Update
The nice people at Westgard sent their
update today. Perhaps a tad dull and dry, but useful stuff applicable to my
daily round. We all need more of this…
11 December 2023 (Monday) - ESR
Here’s something about a new ESR analyser that came via the
nice people at the Medical Laboratory Observer. There are those who are
incredibly scathing about the ESR. There are those who call it a totally
non-specific test and had long since been superseded by all sorts of other
tests.
However I can remember my old GP singing
the praises of the ESR. He told me he had a few minutes with a patient. Were they
ill? Were they looking to get a sick note? He told me that given a high ESR he
knows he has to investigate further, but given a normal result, he can tell the
patient to clear off with a clear conscience.
In the hospital setting the ESR is of
limited use (at best), but for the GP it is invaluable. And that’s why
we keep on doing them.
Subscribe to:
Posts (Atom)





