22 December 2023 (Friday) - Stem Cell Evidence Alert

The Stem Cell Evidence Alert update arrived in my in-box today. There was quite a bit of talk about allogenic stem cell transplants. Back in the day we used to do quite a few of those… but they don’t seem to be anywhere near as common these days.
Perhaps it is a “specialist centre” thing and not something done is the district general hospitals any more?
 

ARTICLE OF THE MONTH

Prospective Multi-Institutional Study of Eculizumab to Treat High-Risk Stem Cell Transplant Associated TMA.Jodele, S., et al. (2023) Blood [record in progress]PICO SUMMARY

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TOP ARTICLES

Peripheral Blood Haploidentical Allogeneic Stem Cell Transplantation in Older Adults with Acute Myeloid Leukemia and Myelodysplastic Syndromes Demonstrates Long Term Survival, Results from the Australasian Bone Marrow Transplant Recipient Registry.Abadir, E., et al. (2023) Transplantation and Cellular Therapy [record in progress]

Fludarabine melphalan versus fludarabine treosulfan for reduced intensity conditioning regimen in allogeneic hematopoietic stem cell transplantation: a retrospective analysis.Chichra, A., et al. (2023) International Journal of Hematology [record in progress].Reconstitution of Natural Killer cells after allogeneic hematopoietic stem cell transplantation is facilitated by Huiyang-Guben decoction through activating the Smad7/Stat3 signal pathway.Gao, X., et al. (2023) Molecular and Cellular Biochemistry [record in progress]

Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study.Gerbitz, A., et al. (2023) Frontiers in Immunology 14:1251593

Peripheral blood haploidentical hematopoietic cell transplantation for patients aged 70 years and over with acute myeloid leukemia or high-risk myelodysplastic syndrome.Harbi, S., et al. (2023) Bone Marrow Transplantation [record in progress]

Chronic graft-versus-host disease is characterized by high levels and distinctive tissue-of-origin patterns of cell-free DNA.Pang, Y., et al. (2023) iScience 26:108160

Assessment of monocytic-myeloid-derived suppressive cells (M-MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients.Peterlin, P., et al. (2023) EJHaem 4 (4):1089-1095

Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease.Strobl, J., et al. (2023) The British Journal of Dermatology [record in progress]

Prophylactic versus Preemptive modified donor lymphocyte infusion for high-risk acute leukemia after allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study.Yang, L., et al. (2023) Bone Marrow Transplantation [record in progress]

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21 December 2023 (Thursday) - Swearing at the BTLP-TACT

Time for a BTLP-TACT exercise… I had two cases:

 

79396 – A thirty-eight year-old chap in the haematology clinic requiring eight units of blood for an exchange transfusion (do they still happen?) for sickle cell disease

He grouped as A Rh(D) Positive with a weak D. With absolutely no idea what the “less than perfect(!)” software was expecting I called it indeterminate. But this is crap isn’t it (to be blunt). Given a patient in the haematology clinic known to have sickle cell disease requiring exchange transfusion, how likely is it that this dubious D group wouldn’t have been encountered and investigated years ago?

The antibody screen was negative, for which I was grateful.

I selected eight units of A Rh(D) Negative blood knowing full well the software wouldn’t be happy. 

16094 – A thirty-three year-old woman needing four units of blood for surgery.

She too was a pain in the glass (as my grandson would say). An indeterminate ABO group but was Rh (D) Negative, and a positive antibody screen (in cells 1 & 2). I selected panels…

The IAT and enzyme panels were positive in cells 1, 2. 3. and 5 corresponding with anti-D and anti-E but not excluding anti-Cw

I selected four units of O Rh(D) Negative which were also E and Cw negative

 
Needless to say I got the thumbs down. I’m not quite sure why though. Apparently I got the group bits right but selected the wrong blood components. But why I’d done that… It wouldn’t tell me. It has to be said that as a learning tool the blood transfusion simulator leaves a lot to be desired in that it seems to work in a way which is at odds to reality, and when you get it wrong it won’t tell you why.

19 December 2023 (Tuesday) - Transfusion Evidence Alert Update

PCC or FFP?  And tranexamic acid yet again!!! The regular update from the nice people at the Transfusion Evidence Alert is always worth having.

ARTICLE OF THE MONTH

Restrictive or liberal transfusion strategy in myocardial infarction and anemia.Carson, J.L., et al. (2023). The New England Journal of Medicine. [Record in progress].PICO Summary available

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TOP ARTICLES

Thalidomide for recurrent bleeding due to small-intestinal angiodysplasia.Chen, H., et al. (2023). The New England Journal of Medicine.

Tranexamic acid for traumatic injury in the emergency setting: a systematic review and bias-adjusted meta-analysis of randomized controlled trials.Fouche, P.F., et al. (2023). Annals of Emergency Medicine. [Record in progress].

Comparative efficacy of early TIPS, non-Early TIPS, and standard treatment in patients with cirrhosis and acute variceal bleeding: a network meta-analysis.Huang, Y., et al. (2023). International Journal of Surgery. [Record in progress].

Randomized trial of hyperimmune globulin for congenital CMV infection - 2-year outcomes.Hughes, B.L., et al. (2023). The New England Journal of Medicine.

Erythropoiesis-stimulating agents and cardiovascular mortality: a systematic review and meta-analysis of 17 studies and 372,156 hemodialysis patients.Karimi, Z., et al. (2023). International Journal of Cardiology. Cardiovascular Risk and Prevention.

Next generation sequencing of red blood cell antigens in transfusion medicine: systematic review and meta-analysis.Matosinho, C.G.R., et al. (2023). Transfusion Medicine Reviews. [Record in progress].

Effects of plasmapheresis frequency on health status and exercise performance in men: a randomized controlled trial.Mortier, A., et al. (2023). Vox Sanguinis. [Record in progress].

Can a checklist facilitate recognition of a transfusion-associated adverse event by prelicensure nursing students?Scott, S.S., et al. (2023). Nurse Educator. [Record in progress].

Prothrombin complex concentrate versus fresh frozen plasma in adult patients undergoing cardiac surgery: a systematic review and meta-analysis.Viana, P., et al. (2023). Journal of Chest Surgery. [Record in progress].

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13 December 2023 (Thursday) - HCPC Update

The HCPC sent their update today. You can read it by clicking here. I read it as I rather feel obliged to do so, and in all honesty didn’t find anything I felt was relevant to me… but this left me rather thoughtful. Bearing in mind it is a professionally produced document, either the person being paid to produce it is the wrong person, or I’m missing the point entirely.
I wonder which it is. I suspect the latter.

12 December 2023 (Tuesday) - BTLP-TACT Exercise

I thought I’d try another BTLP-TACT exercise…
I had one case – an eighty-four year-old chap in A&E requiring group & save. He grouped as O Rh(D) Positive with a negative antibody screen
I got the green light… Bearing in mind the debacle of last time I took screen shots every step of the way today. I can delete them all now.

12 December 2023 (Tuesday) - Westgard QC Update

The nice people at Westgard sent their update today. Perhaps a tad dull and dry, but useful stuff applicable to my daily round. We all need more of this…

11 December 2023 (Monday) - ESR

Here’s something about a new ESR analyser that came via the nice people at the Medical Laboratory Observer. There are those who are incredibly scathing about the ESR. There are those who call it a totally non-specific test and had long since been superseded by all sorts of other tests.
However I can remember my old GP singing the praises of the ESR. He told me he had a few minutes with a patient. Were they ill? Were they looking to get a sick note? He told me that given a high ESR he knows he has to investigate further, but given a normal result, he can tell the patient to clear off with a clear conscience.
In the hospital setting the ESR is of limited use (at best), but for the GP it is invaluable. And that’s why we keep on doing them.