29 March 2023 (Wednesday) - BTLP-TACT Exercise

Time for a BTLP-TAC exercise.
I was presented with two cases

72182 – a thirty four year old woman in the gynaecology department requiring six units of blood as soon as possible.She grouped as A Rh(D) Negative with a negative antibody screen. I selected six A Rh(D) Neg K Neg units (one was irradiated)

89460 – a seventy-seven year old chap in A&E requiring group & save. He grouped as A Rh(D) Positive with a negative antibody screen.

I got the green light

28 March 2023 (Tuesday) - HCPC Newsletter


The HCPC sent their newsletter today. there was quite a bit of talk about the revised standards of proficiency for biomedical scientists…

I’ve had a good look at them… there’s been a few subtle changes to the wording but… will this make a lot of difference to me?

27 March 2023 (Monday) - Transfusion Evidence Alert Update

 The nice people at Transfusion Evidence Library sent their update today. Loads to take in… 


Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial.Al-Ajlan, F.S., et al. (2023). Stroke.

Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis.Beverly, A., et al. (2023). The Cochrane Database of Systematic Reviews.

Pathogen inactivation methods to prevent transfusion-transmissible arboviruses.Giménez-Richarte, Á., et al. (2023). Tropical Medicine & International Health. [Record in Progress].

Convalescent plasma for people with COVID-19: a living systematic review.Iannizzi, C., et al. (2023). The Cochrane Database of Systematic Reviews.

Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial.Lehr, A.R., et al. (2022). Critical Care Medicine.

COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials.Levine, A.C., et al. (2023). Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America. [Record in Progress].

Economic evaluation of ferric carboxymaltose compared with placebo in iron-deficient patients with heart failure: a systematic review.Rezapour, A., et al. (2023). International Journal of Clinical Pharmacy. [Record in Progress].

Topical Tranexamic Acid in Breast Reconstruction: A Double-Blind, Randomized Controlled Trial.Safran, T., et al. (2023). Plastic and Reconstructive Surgery. [Record in Progress].

Clinical Efficacy of Early Administration of Human Immunoglobulin on Children with Severe Hand-foot-mouth Disease.Wu, H., and Li, L., (2023). Journal of the College of Physicians and Surgeons-Pakistan: JCPSP.



Two-year outcomes following a randomised platelet transfusion trial in preterm infants.Moore, C.M., et al. (2023). Archives of Disease in Childhood. Fetal and Neonatal Edition. [Record in Progress].PICO Summary available



24 March 2023 (Friday) - Vitamin E induced coagulopathy


There is a theory that iron therapy can cause inflammations which inhibit iron uptake. Supplementing the iron therapy with vitamin E can reduce the inflammation and enhance the iron uptake.
However too much vitamin E can cause coagulopathy by inhibiting vitamin K-derived coagulation factor synthesis. This can cause serious bleeding events such as gastrointestinal bleeding and intracranial hemorrhage.