The BloodMed email alert came in this morning.
As usual there was all sorts of snippets. I spent a little while perusing the article
on the Pelger-Huet anomaly.
Congenital Pelger-Huët anomaly is a clinically
benign autosomal dominant condition, the overall incidence in the general
population ranges from 0.01%-0.1% Compared to normal neutrophils, PHA
neutrophils have normal bactericidal, metabolic, biochemical and phagocytic
function with a normal life span.
The acquired form, on the other hand, can
result from infection or myelodysplastic syndromes or be induced by drugs such
as tacrolimus or ibuprofen. Morphologically, there are several points to look
at when comparing the two types (PHA: Pelger-Huët anomaly and the PPHA:
acquired or pseudo-PHA);
- The acquired form could have some vacuolation.
- Chromatin clumping usually involves the neutrophils only in the acquired form whereas eosinophils, and basophils are also affected in the congenital form.
- The percentage of the PMN cells with the PHA morphology is really high up to 93% compared to around 38% in the acquired form.
- No cytopenia nor chromosomal abnormalities had been reported in the congenital form in comparison with the acquired one.
