The nice people at the Fritsma Factor sent
their update today. This time there’s quite a bit of stuff which went over
my head. Perhaps it shouldn’t… which is why I do CPD…
This is (supposed to be) a reflective diary by a (not very) anonymous biomedical scientist who works somewhere in the south of England. One day this diary may well be submitted to the Health and Care Professions Council as evidence of ongoing continual professional development....
2 June 2026 (Tuesday) - BTLP-TACT Exercise
I’m always getting prompts to do more
BTLP-TACT exercises, I’ve walked the dogs, and it is raining outside anyway…
I was given two cases:
I was given two cases:
33586 – a thirty-year-old woman with appendicitis needing group and save.She grouped as O Rh(D) Positive with a negative antibody screen.15253 – an eight-one-year-old woman needing four units of blood for a pancreatectomy.She grouped as B Rh(D) Positive with an antibody screen positive in cells 2 & 3.I performed antibody panels.The enzyme and IAT panels were positive in cells 1, 3, 4, 6 & 7 corresponding with anti Jk(a) but not excluding anti-Cw.I scared up four units of various compatible ABO and RH groups that were Jk(a) Negative
I got it wrong…
Anti-Cw *could* have been excluded from the screening panel. Dur !!!
But if that was the only hiccup I’m content. Better to err on the side of caution, eh?
1 June 2026 (Monday) - VEXAS Syndrome
I saw a diagnosis today: VEXAS syndrome.
A new one on me – it is an adult-onset, severe autoinflammatory and blood
disorder caused by a random, acquired mutation in the UBA1 gene. It primarily
affects men over fifty. The name is an acronym outlining its core
characteristics:
· Vacuoles in bone marrow cells
· E1
enzyme malfunction
· X-linked
genetic origin
· Autoinflammation
(immune system attacking healthy tissue)
· Somatic mutation (not inherited)
Here’s a link about it.
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