3 August 2026 (Monday) - Learning Monday

 The correct answer is option 3. Mixed phenotype acute leukemia with KMT2A rearrangement  

Immunophenotypic properties of MPAL can change over time: both variable proportions of different lineages and phenotypic alterations have been described as lineage switch. Most cases of lineage change involve a switch from ALL to AML. A retrospective review can often reveal the presence of an unrecognized or underappreciated malignant subclonal population present in the initial specimen. This may represent a minor population which displayed more chemoresistance and emerged after eradication of the chemosensitive dominant clone. This kind of lineage switch is most common in MPALs with KMT2A rearrangement where a small myeloid/monocytic population can be difficult to appreciate due to hyperleukocytosis with a dominant B-precursor population at diagnosis.

Reference: 

Weinberg OK, Arber DA, Döhner H, et al. The International Consensus Classification of acute leukemias of ambiguous lineage. Blood. 2023;141(18):2275-2277. 

2 August 2026 (Sunday) - Something New

Emperipolesis – that’s a new one on me… apparently it’s a rare biological process where an intact, living cell enters and moves inside the cytoplasm of another cell without getting harmed or destroyed. It differs from phagocytosis because the engulfed cell stays alive and can leave and does…

Here’s a reference about it.