29 July 2021 (Thursday) - HDFN... ?

In pre-history there were a few sub-species of humans that aren’t around any more. Over the years there have been several theories as to why this should be…

Here’s a rather garbled version of the latest theory. Basically all the human sub-species were keen on inter-breeding, but the non-modern-humans had antigens which seemed to provoke immune responses far stronger that those cause by modern humans, and HDFN did for all the other sub-species.

I suppose it is as good a theory as any…

23 July 2021 (Friday) - Current Thinking on MDS

The nice people at the American Society of Hematology sent an update today focussing of the latest treatments for myelodysplastic syndromes. All rather clinical, but all useful stuff…

Rusfertide Helps Patients With Polycythemia Vera Avoid Phlebotomy
Patients with polycythemia vera who received rusfertide were able to avoid therapeutic phlebotomy for seven months, even among those with high-risk disease, according to research presented at EHA2021 Virtual.
Avapritinib Approved for Advanced Systemic Mastocytosis
The FDA has approved avapritinib for the treatment of adult patients with advanced systemic mastocytosis, systemic mastocytosis with an associated hematologic neoplasm, and mast cell leukemia.
Exploring Venetoclax Plus Azacitidine in CMML and MPNs
Results from two recently published studies investigated the treatment combination in patients with chronic myelomonocytic leukemia and myeloproliferative neoplasms, finding that venetoclax plus azacitidine led to high response rates in these disease settings.


23 July 2021 (Friday) - More e-learning

I did some e-learning today – “Blood Components and Indications for Use”. As I did it I planned this blog entry and thought I would say something along the lines of “I didn’t learn anything new but a refresher is always good”, but whilst that turned out to be the case, it probably won’t be so next time. One thing that had become painfully apparent to me over the years is that opinion and practice in blood transfusion is a very changing thing…