8 March 2022 (Tuesday) - Lymphocytosis

 

 

H,22.7467200.N       R 08.03.22  Clin. det.                                    

DIFF Blood Film Review           Diagnosis                                      

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            HBM   WBCM    PLT    HCT   RBCM   MCVM   MCHM  MCHCM    RDW      N

281009 F   12.9   8.39    436  0.404   4.66   86.7   27.7   31.9   13.6   2.89

280916      133   8.40    356  0.415   4.73   87.7   28.1    320   13.0   2.70

240517      128   7.40    359  0.402   4.54   88.5   28.2    318   13.3   1.90

030322 F    135   9.04    422  0.405   4.51   89.8   29.9    333   12.3   3.37

 

              L      M      E      B   RETP   RETA    IRF    NUC     GF    ESR

281009 F   4.53   0.56   0.37   0.04                                          

280916     4.50   0.50   0.50   0.10                                          

240517     4.20   0.60   0.60   0.00                                          

030322 F   4.50   0.86   0.23   0.08  

Here’s something I saw today… the causes of lymphocytosis are an essay in themselves. Some need immediate referral, some just need watching. More and more I’m seeing this sort of thing in people from their thirties to their seventies. Obviously there is some reason for the patient to be having a blood test, but whatever the reason there is a (seemingly) utterly unrelated ongoing mild lymphocytosis. Ongoing over months or years. This one is seemingly unchanged in twelve years.

There are a myriad of papers on the subject – just type “ongoing mild lymphocytosis” into Google to find them. (I won’t other reproducing them here). Bearing in mind that sooner or later the lymphocytosis may well transform into something nastier, the thing here is to keep an eye on the lymphocytosis. Always suggest it be monitored in the comments you write on the blood film.

7 March 2022 (Tuesday) - BTLP - TACT Excercise

 

Time for another BTLP-TACT exercise…
I was presented with one case from the out-patients department; an eighty-four year-old chap requiring group and save prior to surgery for a bladder tumour.
 

The ABO group was indeterminate with cells grouping as “A” but plasma grouping as “O”, but the Rh group was negative.
Possibly a case of A2 with anti-A1, or a cold antibody such as anti-P1 or anti-M? Either way such further investigations are (sadly) beyond t he ability of the BTLP-TACT simulator
 

The antibody screen had weak reactions in all three cells. I requested antibody panels.
The enzyme panel was positive in cells 3 and 5 corresponding with anti-E

The IAT panel was positive in cells 1, 3, 5, 6, 9 & 10 corresponding with anti – Fy(a) but could not rule out anti-Lu(a)

I got the green light… as I should. I must admit I didn’t so much see that as a demonstration of my ability to do blood group serology as a demonstration of my ability to navigate the software…

3 March 2022 (Thursday) - Fritsma Factor Newsletter


The “Fritsma Factor” Newsletter came today. You can see it by clicking here. I was intrigued to see mention of FDP and PIVKA… I (vaguely) remember what they were – now I know what they are in the New World Order. So I’ve learned something and so the day wasn’t entirely wasted.