26 November 2021 (Friday) - Chediak Higashi Syndrome (possibly)

 

An interesting post on the Facebook “Hematology interest Group”. As always there was no indication whatsoever as to what the case was. Several people commented “Chediak Higashi Syndrome”. Was it? I don’t know, but it made me look up on something about which I’d not thought for some time.

https://rarediseases.org/rare-diseases/chediak-higashi-syndrome/
https://medlineplus.gov/genetics/condition/chediak-higashi-syndrome/

https://www.ncbi.nlm.nih.gov/books/NBK507881/

25 November 2021 (THursday) - Transfusion Evidence Alert Update

The Transfusion Evidence Alert email arrived today. As always there was too much to take in at a single sitting, but it is all good stuff. And much of it relevant to what I do.

ARTICLE OF THE MONTH

Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.Estcourt, L.J., et al. (2021). JAMA.PICO Summary available

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TOP ARTICLES

Tranexamic acid for the prevention of postpartum hemorrhage in women undergoing cesarean delivery: an updated meta-analysis.Bellos, I., et al. (2021). American Journal of Obstetrics and Gynecology. [Record in progress]

Promoting awareness of donation-related iron depletion among high risk blood donors.France, J.L., et al. (2021). Transfusion. [Record in progress]

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial.Garbero, E., et al. (2021). Intensive Care Medicine.

Albumin in the management of hepatic encephalopathy: a systematic review and meta-analysis.Is, B., et al. (2021). Annals of Hepatology. [Record in progress]

Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low-to-middle income countries: a systematic review and meta-analysis.Ivain, P., et al. (2021). Journal of Perinatology: Official Journal of the California Perinatal Association.

Prothrombin Complex Concentrate for Trauma Induced Coagulopathy: A Systematic Review and Meta-Analysis.Kao, T.W., et al. (2021). Journal of Acute Medicine.

Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients.Mahmood, A., et al. (2021). Emergency Medicine Journal

A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial. McGuinness, S., et al. (2021). Vox Sanguinis. [Record in progress]

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22 November 2021 (Monday) - UKAS Update

The nice people at UKAS sent their update today. I read it, but can’t help but find myself thinking “what was that all about”? Back when I was a lad, labs didn’t have SOPs and there certainly wasn’t anyone setting a national standard. Having these improved matters no end… but the impetus wasn’t maintained.
Today we have a regulatory framework in which no-one say “this is how you will do a blood count”. Instead we have “this is how you will document that you got the blood count wrong”.
Perhaps the emphasis is in the wrong place. Am I the only one who feels this way? Or perhaps it really is time I should retire?