25 January 2024 (Thursday) - Transfusion Evidence Update

The Transfusion Evidence Alert update arrived today. Quite a lot to take in. The article about conservative vs liberal transfusions (see below) made me think. Back in the day no one’s haemoglobin was allowed to be below 100 g/l. It would seem we were massively over-transfusing back then, and may well be doing so now?
And tranexamic acid? That's the stuff...

Darbepoetin alfa to reduce transfusion episodes in infants with haemolytic disease of the fetus and newborn who are treated with intrauterine transfusions in the Netherlands: an open-label, single-centre, phase 2, randomised, controlled trial.Ree, I.M.C., et al. (2023). The Lancet. Haematology.PICO Summary available

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TOP ARTICLES

Evaluation of the safety and effectiveness of topical intrapleural application of tranexamic acid in thoracic surgery: a systematic review and meta-analysis of randomized controlled trials. Alzahrani, A., et al. (2023). Clinical and Applied Thrombosis/Hemostasis.

Effectiveness of tranexamic acid in the postoperative period in body contour surgery: randomized clinical trial.Bayter-MarĂ­n, J.E., et al. (2023). Plastic and Reconstructive Surgery. Global Open.

Red cell transfusion thresholds in outpatients with myelodysplastic syndromes: combined results from two randomized controlled feasibility studies.Buckstein, R., et al. (2023). American Journal of Hematology. [Record in progress].

Volume replacement in the resuscitation of trauma patients with acute hemorrhage: an umbrella review.Gianola, S., et al. (2023). International Journal of Emergency Medicine.

Meta-analysis and metaregression of the treatment effect of intravenous iron in iron-deficient heart failure.Martens, P., et al. (2023). JACC. Heart Failure. [Record in progress]

Orthopaedic trauma and anemia: conservative versus liberal transfusion strategy: a prospective randomized study.Mullis, B.H., et al. (2024). Journal of Orthopaedic Trauma.

A randomized controlled trial to explore the safety and efficacy of irradiated buffy-coat granulocytes in pediatric patients with febrile neutropenia.Ramachandran, M., et al. (2023). American Journal of Blood Research.

Intravenous albumin in cardiac and vascular surgery: a systematic review and meta-analysis.Skubas, N.J., et al. (2023). British Journal of Anaesthesia. [Record in progress]

The incidence of transfusion-related acute lung injury using active surveillance: a systematic review and meta-analysis.White, S.K., et al. (2023). Transfusion. [Record in progress]


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