The nice
people at “Transfusion News” sent their update today:
Target Trial Emulation Using Real World Data Suggest Older RBCs May Increase Mortality |
 May 11, 2022
Data
from many randomized clinical trials (RCTs) have not found an impact of
storage time of red blood cells on patient outcomes. A newly published
paper, however, questions the outcome and validity of these RCTs noting
inherent clinical, methodological, and statistical problems. Namely,
study arms with substantially different ages of fresh and old cells are
logistically difficult due to the nature of stocking blood, and many of
the RCTs were not powered to detect small but possibly meaningful
effects of storage time. [Read More]
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Tranexamic Acid in Noncardiac Surgeries |
 May 3, 2022
Large
randomized clinical trials have shown that tranexamic acid safely
reduces bleeding in patients undergoing cardiac surgery or cesarean
sections, and evidence from orthopedic surgeries suggest that tranexamic
acid is also safe and effective. Limited data, however, exist for
patients undergoing nonorthopedic or noncardiac surgeries. [Read More]
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