High dose methotrexate infusion is widely used in the treatment of
malignancies such as leukemia, high risk lymphoma, and osteosarcoma. It
can be associated with multiple adverse effects, especially renal
toxicity, which could leads to acute kidney injury (AKI), delaying drug
elimination and worsening its toxicity. Leucovorin, a reduce folic acid,
is commonly used with […]
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