8 March 2023 (Wednesday) - Holi

We had a rather good day today. As part of the trainees’ route to qualification they have to show awareness of “diversity in the workplace”. Back in the day we’d just do an on-line e-learning course and the box would be ticked. These days each trainee picks one cultural event from something that is not from their personal culture and organises a celebration of it. Today Ellie organised a celebration of Holi; a Hindu festival celebrating the arrival of Spring. We all learned something, we all got to scoff samosas, sweeties and cakes, and there was even a (rather demure) bit of face-painting too. I took a few photos of what went on, and the boss suggested that I put them on the works’ Facebook page.
How times change. Where I used to work the mere mention of the workplace on social media was grounds for formal disciplinary action; I still have the written warning for saying that I was tired at 6am on a night shift. In a far better workplace, the use of social media is encouraged.

7 March 2023 (Tuesday) -Fritsma Factor Newsletter

 

The Fritsma Factor newsletter appeared in my in-box this morning. Not quite as full of information as some have been in the past, but a valued resource nonetheless…

6 March 2023 (Monday) - BTLP-TACT Exercise

What with holiday I’ve rather skimped on the BTLP/TACT recently, so I thought I’d have a go at one at four o’clock on a night shift…
 
I had two cases:
 

71528 – a thirty-seven year old woman in theatre needing group and save

She grouped as O Rh(D) Positive with a negative antibody screen

48940 – a thirty year old woman in A&E requiring two units of blood today

She also grouped as O Rh(D) Positive with a negative antibody screen

I selected two units of O Rh(D) Positive K-negative blood

 
I got the green light…

5 March 2023 (Sunday) - Transfusion News Update

 

The nice people at Transfusion News sent their update today. Bearing in mind that antibody titres have been pretty much the only way to judge how a potential case of HDFN is faring, it’s a tad late in the day to cast doubt on the whole thing, isn’t it?

High Variability in Antibody Titer Determination in Transfusion Medicine

March 2, 2023Antibody levels are important for many aspects of clinical care from evaluating the incompatibility of transfusions and transplants to determining certain diagnoses such as hemolytic reactions. Although no gold standard exists to determine antibody levels, the majority of assays depend on titration and grading the strength of agglutination, which has been performed manually and is operator dependent. [Read more]

 

Transfusion Transmission of Hepatitis A Virus during a Recent Epidemic in Europe

February 21, 2023In most infections of hepatitis A (HAV), individuals have very mild symptoms or are asymptomatic. Although rare in the U.S., globally HAV causes about 1.4 million cases and usually spreads via fecal-oral routes; however, case reports have documented transmission by sexual contact and transfusion. An HAV outbreak occurred in Europe from 2016 to 2019, and researchers detected a rising number of HAV cases in Poland between mid-2017 and 2019. [Read more]

28 February 2023 (Tuesday) - Westgard QC Update

 

The nice people at Westgard sent their update today…. You can read it by clicking here.
At the risk of appearing ungrateful, it’s not one of their better ones.

24 February 2023 (Friday) - Transfusion Evidence Alert


The nice people at Transfusion Evidence Alert sent their update today… Just the thing to round off my week’s holiday

ARTICLE OF THE MONTH

Cost-effectiveness of Fibrinogen Concentrate vs Cryoprecipitate for Treating Acquired Hypofibrinogenemia in Bleeding Adult Cardiac Surgical Patients.Abrahamyan, L., et al. (2023). JAMA Surgery. [Record in Progress].PICO Summary available

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TOP ARTICLES

Antifibrinolytics use during surgery for oncological spine diseases: A systematic review.Avila, M.J., et al. (2022). Surgical Neurology International.

The ICaRAS randomised controlled trial: Intravenous iron to treat anaemia in people with advanced cancer - feasibility of recruitment, intervention and delivery.Dickson, E.A., et al. (2023). Palliative Medicine. [Record in Progress].

Foetal haemoglobin inducers for reducing blood transfusion in non-transfusion-dependent beta-thalassaemias.Foong, W.C., et al. (2023). The Cochrane Database of Systematic Reviews.

Impact of time and distance on outcomes following tourniquet use in civilian and military settings: A scoping review.Joarder, M., et al. (2023). Injury. [Record in Progress].

What blood conservation practices are effective at reducing blood sampling volumes and other clinical sequelae in intensive care? A systematic review.Keogh S., et al. (2023). Australian Critical Care. [Record in Progress].

Should adding pain, oxygen saturation and physical assessment to vital signs become the new standard of care for detecting blood transfusion reactions?Roney, J.K., et al. (2022). Vox sanguinis.

The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial.Steffen, K.M., et al. (2023). Pediatric Critical Care Medicine.

Benefits of pre-operative oral Sucrosomial(®) iron supplementation in cardiac surgery: influence of patient's baseline hemoglobin and gender.Weltert, L.P., et al. (2022). Blood Transfusion. [Record in Progress].

Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.Denkinger, C.M., et al. (2022). Nature Cancer.

17 February 2023 (Friday) - Transfusion News Update

 

Whole blood was coming back… or so I thought a couple of weeks ago. Now… not so sure…

Increased Blood Use and Cost for Emergency Transfusions with Whole Blood Compared to Packed Red Blood Cells

February 16, 2023In the past two decades, a growing number of hospitals have started using whole blood to treat trauma patients and those who need emergency transfusions based on prior evidence from both military and civilian studies. A new retrospective study of patients at Massachusetts General Hospital in Boston, however, questions the benefits of using whole blood for emergency transfusions. [Read more]

 

Thromboelastometry and Clinical Guidance for Fibrinogen Infusions during Liver Transplantation

February 8, 2023Thromboelastometry provides individualized measures of clot kinetics and structure, and has played an increasingly important role in the management of coagulopathy during liver transplants and other traumatic bleeding events. Thromboelastometry for fibrin function (FIBTEM) also predicts transfusion needs during liver transplants. [Read more]