8 July 2021 (Thursday) - Transfusion News Update


 The Transfusion News update appeared in my in-box this morning. All good stuff…

Gunshot Wounds Cause Significant Mortality, Blood Utilization, and Health Care Costs in the U.S.

July 6, 2021
Half of the world’s civilian firearms are owned by individuals in the United States. The U.S. also leads all high-income countries for gunshot wound (GSW)-related deaths, yet little is known about the blood utilization patterns in GSW victims. Researchers analyzed data from the 2016-2017 National Inpatient Sample and National Emergency Department Sample, which included 58,815 weighted inpatient hospitalizations from GSWs and 168,315 weighted emergency department visits due to GSWs. [Read More]


 

Reducing Red Cell Use for Patients with Sickle Cell Disease during a Pandemic

June 30, 2021
Since March 2020, the COVID-19 pandemic has strained blood inventories, so researchers at one Philadelphia hospital implemented new measures to reduce blood use in patients with sickle cell disease (SCD). Fifty patients (mean age, 23.5 years [range: 9 to 44 years]) with SCD requiring chronic red cell exchanges every 3 to 5 weeks were followed for 6 months from March 2020 to September 2020 to determine if two new measures reduced blood usage. [Read More]

 

Tracking HIV Drug Resistance and Subtypes in Blood Donors

June 22, 2021
The risk of HIV transmission from blood transfusion is low (0.16 to 0.49 per million transfusions) but is still possible due to the viral window period during which newly acquired infections are not detected by diagnostic screening methods. In Poland, the frequency of HIV-positive blood donors and donations per 100,000 was 6.6 and 3.3, respectively. Therefore, constant hemovigilance is needed to identify pre-seroconversion infections, but samples can also be used to study HIV genetic diversity and drug resistance patterns. [Read More]

 

7 July 2021 (Wednesday) - K-Typing

A very valid reason for doing CPD is to keep up-to-date with current trends and practices. It has to be said they change at breakneck speed in blood transfusion.

Take fresh frozen plasma… When I was a lad the stuff only came in A and AB flavours. There was (supposedly) no need for blood group O FFP. Then the stuff came out, and there was (so it was claimed) no need to look at the labels. Anyone could have FFP of any group. Nowadays giving O FFP to a non O recipient is a “never-event”.
Take single unit transfusions. Back in the day it was widely said that the dangers of a single unit transfusion greatly outweighed the benefits. Nowadays single unit transfusions are the norm.
 

But things don’t just change over time. They change from place to place. Here in the UK is it standard practice to make sure that *all* women of childbearing age receive K-negative blood products. That is *all* women without exception !!!

Someone from America posted on the Facebook “Blood Bank Professionals Group” this morning saying that an obstetrician had asked for K-negative blood for his patient. All the UK-based people commented “well so he should”, and all the American-based people laughed.
I suppose the difference is that in the UK pretty much all of the donor blood is K-typed whereas in America the patient would be billed for the typing, but it did bother me somewhat to see posts from American lab people who were saying how easy it is to get K-negative blood for someone with anti-K antibodies (which it is), but at the same time were seemingly oblivious to the dangers of HDFN due to anti-K antibodies.

 

7 July 2021 (Wednesday) -BTLP-TACT Excercise

Time for another BTLP-TACT exercise…

I was given two cases 

69866 – a thirty-two year-old woman in the ante-natal department requiring group and save.
She grouped as O Rh(D) Negative with a negative antibody screen
 

74949 – a fifty-three year-old chap in the haematology clinic requiring two units of blood on the following day.
He grouped as O Rh(D) Positive with a negative antibody screen. Now no special requirements for blood had been specified and with only four irradiated units of O Rh(D) Positive in the fridge I selected two units of K-Negative non-irradiated blood

I got the green light