29 June 2021 (Tuesday) - Electronic Issue Training

 


I had a little session with one of the seniors today going over the fundamentals of electronic issue this morning with a view to its implementation in a month's time. It all seemed rather straightforward but then, doesn't everything in the training environment. How well it works at 3am when I am on my own and tearing out my few remaining hairs remains to be seem.

28 June 2021 (Monday) - Leukaemia ?


The nice people at Lablogatory sent a case study today. You can read it by clicking here. Back in the day we would have described it as aleukaemic leukaemia.

It is one of those cases of acute leukaemia in which the white cell count *doesn’t* go through the roof. Something to bear in mind when you see iffy looking cells. Just because the white cell count isn’t ten times what you might expect doesn’t mean it isn’t leukaemia..


28 June 2021 (Monday) - e-learning Updates

I did some e-learning today. I started with a refresher on the use of anti-D in the midwifery setting. A refresher is always good… and then I did a refresher on GMP… 

Perhaps I wasn't in the best of frames of mind when I did this... Don't get me wrong - I fully understand the need for audit and documentation and control of what goes on in labs. However is it necessary to labour the point in such pedantic and petty detail? Does an encyclopaedic knowledge and recall of which regulatory body does what actually improve what goes on in the labs?

I think the relevance of the stuff is summed up when I say that I really don’t know what the acronym GMP stands for.

More and more I'm coming to the conclusion that it will very soon be time for me to retire...

25 June 2021 (Friday) - Myeloma


The nice people at the American Society of Hematology sent their update today. Focussing on myeloma it was rather clinical in outlook, but it is all useful stuff…

Here are the highlights in multiple myeloma:
Does Rheumatic Disease Increase Risk of MGUS Progression to Hematologic Malignancies?
Patients with MGUS and concomitant non-antibody–mediated inflammatory rheumatic diseases are at increased risk of progression to overt multiple myeloma, compared with patients who have MGUS without associated rheumatic diseases.
Older Patients With Myeloma May Have Suboptimal Response to COVID-19 Vaccination
These patients experienced reduced efficacy with Pfizer/BioNTech’s COVID-19 vaccine. However, certain factors identified patients who had a higher probability of immune response to vaccination, such as normalized immunoglobulins.
Idecabtagene Ciloleucel Induces Deep Responses in Relapsed/Refractory Multiple Myeloma
Treatment with idecabtagene ciloleucel showed encouraging efficacy in patients with heavily pretreated relapsed and/or refractory multiple myeloma, according to results from the phase II KarMMa study.

25 June 2021 (Friday) - IBMS Newsletter

The IBMS sent their newsletter today. I mention it because I feel I should mention my professional body, and because it is they who will pass judgement on how good (or not!) I am doing with recording my CPD.

However…

I do feel (rather strongly) that as far as CPD goes I have (yet again) been let down by them. Again the newsletter is very light on anything practical; preferring to focus on people. I suppose that the IBMS Newsletter is only as good as the articles they get sent. I *really* should stop grumbling about it and start contributing…


24 June 2021 (Thursday) - NEQAS Parasitology


Two months ago I looked at the NEQAS parasitology blood film CPD. Today I finally got to see the result.
At the time I saw:

 

2102 PA1 

No parasites seen (100) 

 

2102 PA2 

 Microfilaria (105) 

 

I got both correct.


24 June 2021 (Thursday) - NEQAS Blood Films


Two months ago I looked at the NEQAS blood film CPD. Today I finally got to see the result.

 

At the time I saw:

 

2103BF1 

 

Sickle cells           (013) 

Target cells         (010) 

NRBCs                   (022) 

Polychromasia   (005) 

Fragments          (012) 

 

? sickle cell crisis 

 

2103 BF2 

 

Target cells                         (010) 

Howell-Jolly bodies         (020) 

Macrocytosis                     (003) 

Spherocytes                       (016) 

Fragments                          (012) 

 

?? post splenectomy (poor film) 

 

The top ten features (and diagnosis) were

 

2103BF1 

 

Sickle cells           (013) 

NRBCs                   (022) 

Polychromasia   (005) 

Howell-Jolly bodies         (020) 

Target cells         (010) 

 

Fragments came in at #8

 

This was indeed a case of sickle cell crisis 

 

2103 BF2 

 

Howell-Jolly bodies         (020) 

Target cells                         (010) 

NRBCs                   (022) 

Hypochromia

Macrocytosis                     (003) 

 

Fragments came in at #7 and spherocytes  at #10

 

This was a post splenectomy case. No mention was made of the poor film quality though.

 

I’ll take that as having got it right…