At
last…. For once…. So often this cpd lark
is very “theoretical” and “reflective” but today the nice people at
lablogatory sent me something directly useful. A review of cytoplasmic
vacuolation in early cells.
“Every
hematopathologist and pathology trainee knows to be wary of the myriad of
causes that could mimic the dysplastic changes seen in marrows involved by MDS.
Many times morphology alone, without genetic or cytogenetic evidence of
clonality can be tricky. The list of things that can recapitulate changes seen
in MDS seems to grow longer every day – and with it the length of our ‘canned
comments’ on ruling out reactive causes of dysplasia. Within the recent past,
two bone marrow biopsies crossed my microscope, both sent to ‘rule out’ MDS.
Both had almost identical morphologic findings, but very different diagnoses…”
