Saw this
yesterday… Looks like haemoglobin C crystals to me…
Tuned in
late today – it was. “The blood smear shows Hemoglobin C (HbC) crystals in a
patient with hemoglobin C disease. HbC crystals form when a mutation in the
beta-globin chain of hemoglobin replaces glutamic acid with lysine. This
mutation makes HbC less soluble than HbA, forming hexagonal crystals (HbC
crystals as seen in the peripheral smear). Individuals with one HbA gene and
one HbC gene exhibit the HbC trait and are typically asymptomatic. In contrast,
those with homozygous mutations for HbC have hemoglobin C disease, characterized
by mild and chronic hemolytic anemia.”
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