Platelet
clumping is a widely recognised problem when trying to count platelets. All the literature
had always claimed it to be an issue related to the anticoagulant EDTA.
However it
has been my experience that whilst some patients always show platelet clumping,
in others it is intermittent. And whilst in some patients taking a sample into
sodium citrate cures the clumping, in others it does not.
It would
seem that current
opinion is that platelet clumping is more due to pre-analytical issues.
Which might explain why platelet clumps come and go.
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