14 December 2022 (Wednesday) - Transfusion Evidence Alert Update

The nice people at Transfusion Evidence Alert sent their update today… loads of stuff. Fresher blood or older blood… transfusion thresholds… there’s been all sorts of theories about these questions for as long as there has been people asking them.

Sooner or later someone will come out with a definitive answer.

Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials. Stanworth, S.J., et al. (2004). British Journal of Haematology. * Nomination by Professor Nicola Curry, Consultant Haematologist in Oxford. Safety of blood donation from individuals with treated hypertension or non-insulin dependent type 2 diabetes - a systematic review. Stainsby, D., et al. (2010). Vox Sanguinis. * Nomination by Professor Simon Stanworth, Professor of Haematology and Transfusion Medicine, University of Oxford and Consultant Haematologist, NHS Blood and Transplant, Oxford. Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis. Holst, L.B., et al. (2015). BMJ. * Nomination by Dr Antony Palmer, Consultant Orthopaedic Surgeon and Senior Clinical Research Fellow in Oxford. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. Docherty, A.B., et al. (2016). BMJ.  * Nomination by Dr Akshay Shah, NIHR Academic Clinical Lecturer in Intensive Care Medicine, University of Oxford and Honorary Specialty Registrar in Anaesthesia, Oxford University NHS Foundation Trust. Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion. Heddle, N.M., et al (2016). The New England Journal of Medicine. * Nomination by Associate Professor Zoe McQuilten, Consultant Haematologist, Monash University, Australia. Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials. Desborough, M.J., et al. (2017). Journal of Thrombosis & Haemostasis. * Nomination by Dr Mike Desborough, Consultant Haematologist in Oxford. Randomized Trial of Platelet-Transfusion Thresholds in Neonates. Curley, A., et al. (2019). The New England Journal of Medicine. * Nomination by Professor Lise Estcourt, Consultant Haematologist and Associate Professor of Haematology and Transfusion Medicine, University of Oxford; Clinical Lead for the National Comparative Audit in Blood Transfusion, Director of NHSBT Clinical Trials Unit and Associate Medical Director (AMD) – Research, Development and Quality Improvement – Transfusion, NHS Blood and Transplant, Oxford. Transfusion thresholds for guiding red blood cell transfusion. Carson, J.L., et al. (2021). The Cochrane database of Systematic Reviews. * Nomination by Professor Pierre Tiberghien, President of the European Blood Alliance.

A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Hébert, P.C., et al. (1999). New England Journal of Medicine. * Nomination by Professor Mike Murphy, Professor of Transfusion Medicine, Oxford