Here’s something from the nice people at Lablogatory which mad me think… A chap with toothache who had put off going to the dentist because of the ongoing COVID-19 pandemic…
I wonder just how many other such cases are going to be missed?
This is (supposed to be) a reflective diary by a (not very) anonymous biomedical scientist who works somewhere in the south of England. One day this diary may well be submitted to the Health and Care Professions Council as evidence of ongoing continual professional development....
18 February 2021 (Thursday) - Transfusion Evidence Alert
The nice people at the Transfusion Evidence Alert sent their update today. Several useful articles. I actually did read some, but not others. By listing them here I can come back to those ones later…
Red
blood cell transfusions and the survival in patients with cancer
undergoing curative surgery: a systematic review and meta-analysis.
Petrelli, F., et al. (2021). Surgery Today. [Record in progress]
Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses.
Tseng, CH., et al. (2020). Critical Care.
Tourniquet use for knee replacement surgery.
Ahmed, I., et al. (2020). The Cochrane Database of Systematic Reviews.
Association between preoperative blood transfusion and postoperative venous thromboembolism: Review meta-analysis.
Wang, C., et al. (2020). Annals of Vascular Surgery. [Record in progress]
Safety
and Efficacy of Intravenous Iron Sucrose versus Low Molecular Weight
Iron Dextran for Treatment of Iron Deficiency Anemia in Pregnancy: A
Randomized Controlled Trial.
Samsudin, S., et al. (2020). International Journal of Women's Health.
Randomized controlled trial of 7, 28, vs 42 day stored red blood cell transfusion on oxygen delivery (VO(2) max) and exercise duration. Bennett-Guerrero, E., et al. (2020). Transfusion. [Record in progress]
Efficacy of Tranexamic Acid in Reducing Blood Loss in Lower Segment Cesearean Section: A Randomised Controlled Study.
Hemapriya, L., et al. (2020). Journal of Obstetrics and Gynaecology of India.
16 Feruary 2021 (Tuesday) - Stem Cell Evidence Alert Update
The nice people at the Stem Cell Evidence Alert sent their update today. Much of it went over my head, but there were one or two snippets in there…
ARTICLE OF THE MONTH Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial. |
NEW CLINICAL COMMENTARY / REVIEW Total
Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A
Multinational, Randomized, Noninferiority Phase III Study |
SELECTED ARTICLES
Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma.
Baertsch, M. A., et al. (2021) Blood Cancer Journal 11(1):1.
Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia.
Craddock, C., et al. (2021) Journal of Clinical Oncology [record in progress].
Carfilzomib,
lenalidomide, dexamethasone, and cyclophosphamide (KRdc) as induction
therapy for transplant-eligible, newly diagnosed multiple myeloma
patients (Myeloma XI+): Interim analysis of an open-label randomised
controlled trial.
Jackson, G. H., et al. (2021) PLoS Medicine 18(1):e1003454.
Lenalidomide
maintenance after autologous haematopoietic stem-cell transplantation
in mantle cell lymphoma: results of a Fondazione Italiana Linfomi (FIL)
multicentre, randomised, phase 3 trial.
Ladetto, M., et al. (2021) The Lancet. Haematology 2021;8(1):e34-e44.
Randomized phase II trial of extracorporeal phototherapy and steroids vs. steroids alone for newly diagnosed acute GVHD.
Mehta, R.S., et al (2021) Bone marrow transplantation [record in progress]
Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome
Myllymäki, M., et al. (2020) Blood 136(26):3070-3081.
Clinical
characteristics and outcomes of COVID-19 in haematopoietic stem-cell
transplantation recipients: an observational cohort study.
Sharma, A., et al. (2021) The Lancet. Haematology [record in progress].
Autologous
stem cell transplantation versus bortezomib for the first line
treatment of systemic light chain amyloidosis in the UK.
Sharpley, F.A., et al (2021) European Journal of Haematology [record in progress]
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins, B., et al (2021) Journal of Clinical Oncology [record in progress].
14 February 2021 (Sunday) - Atypical Lymphs in COVID-19
Here’s an interesting article that appeared on the Facebook Hematology Interest group page.
The article on Facebook referred to something published in the British Journal of Medicine, and said “This study was published in the British Journal of Medicine on the Prognostic value of atypical lymphs in Covid patients. It is a scientific research publication, so maybe a little long for some people. No time to read? The Introduction in the beginning and the discussion and conclusion at the end maybe of interest to our members”
Since alacrity
is advised, here’s the conclusion:
In summary, this paper has three main contributions:
1.We found that RL circulating in blood in COVID-19 patients are related to a better evolution and prognosis.
2.We demonstrated that these atypical reactive lymphoid cells can be detected by morphology in the smear review, being the computerised approaches proposed herein useful to enhance a more objective recognition.
3.We found that the presence of RL in COVID-19 patients suggests an abundant production of virus-specific T cells, thus explaining the better outcome of patients showing these cells circulating in blood.
The second point isn’t written very well, but it implies that an automated microscope is more objective and reproducible than one operated by human observer. I suspect there is a lot of truth in that…
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