Threshold
levels for transfusions, blood groups and COVID, creating rare antigens on red
cells… as always the Transfusion News update is well worth having…
Transfusion Thresholds for Patients Receiving ECMO |
 November 2, 2022
Venovenous
extracorporeal membrane oxygenation (ECMO) can be used to help provide
respiratory support to patients with severe acute respiratory distress
syndrome (ARDS). Since hemoglobin is essential for oxygen delivery, the
general practice has been to maintain hemoglobin levels in the normal
range during ECMO to maximize oxygen delivery. [Read more]
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ABO and Lewis Blood Groups Linked to Lower COVID-19 Susceptibility |
 October 26, 2022
Blood
group O has been associated with decreased risk of SARS-CoV-2 infection
in several small studies. In order to confirm these observations and
determine if other blood groups are associated with SARS-CoV-2
infection, researchers in Denmark utilized data from the nationwide
SCANDAT database. [Read more]
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Pluripotent Stem Cell Gene Editing Provides Rare RBC Screening Cells |
 October 19, 2022
Over
10 million of RBC units are transfused each year in the U.S. alone.
Alloimmunization and hemolytic transfusion reactions pose a special
challenge for those patients who are chronically transfused. While there
are more than 350 RBC antigens identified, the Rh locus is highly
immunogenic and has hundreds of variants owing to the large number of
single-nucleotide polymorphisms, gene rearrangements and variable
expression of the gene. [Read more]
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