A patient was
admitted for blood transfusion who was known to have anti-Chido antibodies. The
patient’s records said:
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Anti-Chido present.
Conduct antibody panel and
crossmatching as follows: Pool together plasma from three male group O
patients (antibody screens negative).
Add equal volumes of this
pooled plasma to your patient plasma in a 1 to 1 ratio. Use this plasma mix
to perform your antibody panel and crossmatch.
If red cell products have
been transfused since the last NHSBT testing, refer samples to NHSBT to
determine if further allo antibodies have been produced.
If no transfusion has
occured (weak reactions may still be obtained) or, the antibody screen is
negative, it is safe to issue red cells that are least reactive.
Select group O, rr, K- red
cells.
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Seemed
odd to me… on further reading the Chido antigen is part of the complement
cascade, so pooling with normal plasma will mop up any anti-Chido and so any
reaction found in this pooled plasma will be “genuine” blood group antibodies.
There is quite a bit
on the subject available on-line; especially at:
Mind you I have no
idea why the pool has to be from male patients; nor does anyone else that I ask…
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