25 September 2023 (Monday) - Harlequin Cells

Here’s something I don’t see every day… or every year come to that. A harlequin cell. This one was in the blood film of a chap with CLL whose white cell count was over 100. I only saw the one despite some serious searching for more.
Harlequin cells are dysplastic eosinophils with large purple-violet granules resembling basophilic granules. The literature would have me believe that they are commonly observed in acute and chronic myeloid leukaemias… I probably have seen them before but I can’t say I remember seeing one.
Here’s a few references about the things:

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