Administration of Fibrinogen Concentrate during Cardiac Surgery Does Not Significantly Reduce Blood Loss
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March 1, 2017
Since fibrinogen plays a key role in hemostasis and it is rapidly depleted during cardiac surgery, many cardiac surgeons give fibrinogen to control bleeding during surgery for high-risk patients. The efficacy of this treatment, however, had not been previously confirmed in large, randomized clinical trials. A recent study in the Netherlands randomized 120 high-risk cardiac [Read More]
Since fibrinogen plays a key role in hemostasis and it is rapidly depleted during cardiac surgery, many cardiac surgeons give fibrinogen to control bleeding during surgery for high-risk patients. The efficacy of this treatment, however, had not been previously confirmed in large, randomized clinical trials. A recent study in the Netherlands randomized 120 high-risk cardiac [Read More]
Patients with Hematologic Cancers Have Lower Rates of Alloimmunization with RhD
Over 20% of RhD-negative non-oncology patients exposed to RhD-positive red blood cells (RBCs) become alloimmunized to the RhD antigen. In oncology patients, however, the rate of alloimmunization is much lower because cancer patients are often immunosuppressed. Since the availability of RhD-negative RBCs is limited, researchers retrospectively investigated 4295 transfusions of RhD-positive RBCs that occurred in [Read More]
Zika-Positive Blood Donations Can Be Inactivated Using Pathogen Inactivation Technologies
Emerging infections, such as the Zika virus (ZIKV), continue to surface due to global travel, migration, and the spread of vectors including mosquitoes. The first ZIKV outbreak occurred in 2007 in the Pacific and has quickly spread to most of the Americas. Blood donations have tested positive [Read More]
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