I went to a seminar last
week - forgot to write it up...
Rivaroxaban is an orally
active direct factor Xa inhibitor. Rivaroxaban is well absorbed from
the gut and maximum inhibition of factor Xa activity occurs about
four hours after a dose; however the effects last between 8 to 12
hours. Therefore unlike warfarin only one dose per day is necessary
which leads to greater compliance.
Bearing in mind factor Xa
activity does not return to normal within 24 hours so once-daily
dosing is possible.
With lower reported
mortality and morbidity than that reported for warfarin added to no
need for continual INR measurements rivaroxaban and other new oral
anticoagulants such as Dabigatran are becoming more common.
But they are
anticoagulants: and as such they will have a direct effect on
laboratory coagulation investigations. Something to bear in mind when
faced with prolonged clotting times and a rather non-committal
diagnosis.
http://practical-haemostasis.com/Miscellaneous/Useful%20Information/haemostatic_drugs.html
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