10 April 2014 (Thursday) - Rivaroxoban
I went to a seminar last week - forgot to write it up...
Rivaroxaban is an orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa activity occurs about four hours after a dose; however the effects last between 8 to 12 hours. Therefore unlike warfarin only one dose per day is necessary which leads to greater compliance.
Bearing in mind factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.
With lower reported mortality and morbidity than that reported for warfarin added to no need for continual INR measurements rivaroxaban and other new oral anticoagulants such as Dabigatran are becoming more common.
But they are anticoagulants: and as such they will have a direct effect on laboratory coagulation investigations. Something to bear in mind when faced with prolonged clotting times and a rather non-committal diagnosis.
Labels: cpd talk