3 November 2024 (Sunday) - Slide Saturday Challenge

The American Society of Hematology sent out their “Slide Saturday Challenge” yesterday. There’s a hypersegmented neutrophil and macrocytosis. There’s also anisopoikilocytosis and tear drop cells seen.
My gut feeling is that this is a case of megaloblastic anaemia caused by a deficiency of vitamin B12 or folate.
But…
If that were the case wouldn’t there be Howell-Jolly bodies? Was it a case of myelodysplasia? In the end I thought that a case of myelodysplasia wouldn’t have that neutrophil and I went for megaloblastic anaemia.
I was right to do so.
 
For all that this is Slide Saturday Challenge I shall continue posting this on Sunday once the proper answer has come up. As I have said before, on-line morphology does tend to attract those who really haven’t got a clue. No matter what the case presented answers usually range from piles through to dead for three weeks, and the more clueless and wrong the suggestion, the more aggressively it is posted.

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