25 July 2017 (Tuesday) - D dimer

An interesting refresher on d-dimers:

“The D-Dimer is a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample. A D-dimer is released when a blood clot begins to break down… read more ”

24 July 2017 (Monday) - ASH Update

An update from the American Society of Hematology:

ASH Clinical News provides daily news and updates from the hematology/oncology community.

Public Comment Period for Guidelines on Venous Thromboembolism The American Society of Hematology (ASH) is seeking comments on draft recommendations for guidelines for venous thromboembolism (VTE): Pediatric VTE Prevention of VTE in nonsurgical patients The public comment period is July 24 – August 25. Materials are available at: hematology.org/Guidelines-Public-Comment

FDA Approves First New Sickle Cell Treatment in Nearly 20 Years The U.S. Food and Drug Administration has approved oral L-glutamine powder for the treatment of sickle cell disease, finding that it significantly reduces associated complications. CMS Proposes Cuts to 340B Reimbursement The Centers for Medicare and Medicaid Services is considering reducing how much it pays hospitals for drugs purchased through its 340B program to cut out-of-pocket costs for Medicare patients. Cancer Deaths Occur More in Rural America According to CDC Report A new Centers for Disease Control and Prevention report shows that the cancer mortality rate is higher in rural regions and is likely related to a lack of preventive medicine options.

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20 July 2017 (Thursday) - Blood email

I got emailed “Blood” today…. Quite interesting. Several things to pique my interest:

INSIDE BLOOD COMMENTARIES

• Red Cells, Iron, and Erythropoiesis

  Ironing out the role of hepcidin in infection

  Josef T. Prchal

  Blood 2017 130:233-234; doi: https://doi.org/10.1182/blood-2017-05-783688
• Clinical Trials and Observations

  Check this checkpoint inhibitor in lymphoma

  Fernando Cabanillas and Noridza Rivera

  Blood 2017 130:234-235; doi: https://doi.org/10.1182/blood-2017-05-786293
• Hematopoiesis and Stem Cells

  Choosing wisely: RUNX1 alternate promoter use

  Alan B. Cantor

  Blood 2017 130:236-237; doi: https://doi.org/10.1182/blood-2017-06-786228
• Lymphoid Neoplasia

  CD70 turns on NK cells to attack lymphoma

  Todd A. Fehniger

  Blood 2017 130:238-239; doi: https://doi.org/10.1182/blood-2017-06-786244
• Lymphoid Neoplasia

  Might broader be better?

  Amy J. Johnson

  Blood 2017 130:239-240; doi: https://doi.org/10.1182/blood-2017-03-770206
• Thrombosis and Hemostasis

  Prenatal diagnosis by droplet digital PCR

  Margaret V. Ragni

  Blood 2017 130:240-241; doi: https://doi.org/10.1182/blood-2017-05-786269
• Transplantation

  Raising the bar for chronic GVHD trials

  Nicolaus Kröger

  Blood 2017 130:241-242; doi: https://doi.org/10.1182/blood-2017-05-786285
• Clinical Trials and Observations

  A new therapeutic strategy for atypical HUS

  Joel L. Moake

  Blood 2017 130:243-244; doi: https://doi.org/10.1182/blood-2017-06-783704

PLENARY PAPER

• Red Cells, Iron, and Erythropoiesis

  Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron

  Deborah Stefanova, Antoan Raychev, Joao Arezes, Piotr Ruchala, Victoria Gabayan, Mikael Skurnik, Barbara J. Dillon, Marcus A. Horwitz, Tomas Ganz, Yonca Bulut and Elizabeta Nemeth

  Blood 2017 130:245-257; doi: https://doi.org/10.1182/blood-2017-03-772715

REVIEW ARTICLE

• CME Article

  Can histologic transformation of follicular lymphoma be predicted and prevented?

  Robert Kridel, Laurie H. Sehn and Randy D. Gascoyne

  Blood 2017 130:258-266; doi: https://doi.org/10.1182/blood-2017-03-691345

CLINICAL TRIALS AND OBSERVATIONS

• Brief Report

  Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma

  Pier Luigi Zinzani, Vincent Ribrag, Craig H. Moskowitz, Jean-Marie Michot, John Kuruvilla, Arun Balakumaran, Yayan Zhang, Sabine Chlosta, Margaret A. Shipp and Philippe Armand

  Blood 2017 130:267-270; doi: https://doi.org/10.1182/blood-2016-12-758383

HEMATOPOIESIS AND STEM CELLS

• Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors

  Julia E. Draper, Patrycja Sroczynska, Hui Sun Leong, Muhammad Z. H. Fadlullah, Crispin Miller, Valerie Kouskoff and Georges Lacaud

  Blood 2017 130:271-284; doi: https://doi.org/10.1182/blood-2016-06-723635

IMMUNOBIOLOGY

• CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

  Diogo Gomes-Silva, Madhuwanti Srinivasan, Sandhya Sharma, Ciaran M. Lee, Dimitrios L. Wagner, Timothy H. Davis, Rayne H. Rouce, Gang Bao, Malcolm K. Brenner and Maksim Mamonkin

  Blood 2017 130:285-296; doi: https://doi.org/10.1182/blood-2017-01-761320

LYMPHOID NEOPLASIA

• CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies

  Mohamad F. Al Sayed, Carla A. Ruckstuhl, Tamara Hilmenyuk, Christina Claus, Jean-Pierre Bourquin, Beat C. Bornhauser, Ramin Radpour, Carsten Riether and Adrian F. Ochsenbein

  Blood 2017 130:297-309; doi: https://doi.org/10.1182/blood-2016-12-756585
• Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL

  Tabea Erdmann, Pavel Klener, James T. Lynch, Michael Grau, Petra Vočková, Jan Molinsky, Diana Tuskova, Kevin Hudson, Urszula M. Polanska, Michael Grondine, Michele Mayo, Beiying Dai, Matthias Pfeifer, Kristian Erdmann, Daniela Schwammbach, Myroslav Zapukhlyak, Annette M. Staiger, German Ott, Wolfgang E. Berdel, Barry R. Davies, Francisco Cruzalegui, Marek Trneny, Peter Lenz, Simon T. Barry and Georg Lenz

  Blood 2017 130:310-322; doi: https://doi.org/10.1182/blood-2016-12-758599
• Brief Report

  Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

  Janine Schmidt, Joan Enric Ramis-Zaldivar, Ferran Nadeu, Blanca Gonzalez-Farre, Alba Navarro, Caoimhe Egan, Ivonne Aidee Montes-Mojarro, Teresa Marafioti, Jose Cabeçadas, Jon van der Walt, Stefan Dojcinov, Andreas Rosenwald, German Ott, Irina Bonzheim, Falko Fend, Elias Campo, Elaine S. Jaffe, Itziar Salaverria and Leticia Quintanilla-Martinez

  Blood 2017 130:323-327; doi: https://doi.org/10.1182/blood-2017-03-776278

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

• Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils

  Zakir Khan, Xiao Z. Shen, Ellen A. Bernstein, Jorge F. Giani, Masahiro Eriguchi, Tuantuan V. Zhao, Romer A. Gonzalez-Villalobos, Sebastien Fuchs, George Y. Liu and Kenneth E. Bernstein

  Blood 2017 130:328-339; doi: https://doi.org/10.1182/blood-2016-11-752006

THROMBOSIS AND HEMOSTASIS

• Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers

  Irena Hudecova, Peiyong Jiang, Joanna Davies, Y. M. Dennis Lo, Rezan A. Kadir and Rossa W. K. Chiu

  Blood 2017 130:340-347; doi: https://doi.org/10.1182/blood-2016-12-755017

TRANSPLANTATION

• T-cell expression of AhR inhibits the maintenance of pT_reg cells in the gastrointestinal tract in acute GVHD

  Trisha A. Dant, Kaifeng L. Lin, Danny W. Bruce, Stephanie A. Montgomery, Oleg V. Kolupaev, Hemamalini Bommiasamy, Lisa M. Bixby, John T. Woosley, Karen P. McKinnon, Frank J. Gonzalez, Bruce R. Blazar, Benjamin G. Vincent, James M. Coghill and Jonathan S. Serody

  Blood 2017 130:348-359; doi: https://doi.org/10.1182/blood-2016-08-734244
• An endpoint associated with clinical benefit after initial treatment of chronic graft-versus-host disease

  Paul J. Martin, Barry E. Storer, Yoshihiro Inamoto, Mary E. D. Flowers, Paul A. Carpenter, Joseph Pidala, Jeanne Palmer, Mukta Arora, Madan Jagasia, Sally Arai, Corey S. Cutler and Stephanie J. Lee

  Blood 2017 130:360-367; doi: https://doi.org/10.1182/blood-2017-03-775767

LETTERS TO BLOOD

• Eculizumab cessation in atypical hemolytic uremic syndrome

  Samuel A. Merrill, Zachary D. Brittingham, Xuan Yuan, Alison R. Moliterno, C. John Sperati and Robert A. Brodsky

  Blood 2017 130:368-372; doi: https://doi.org/10.1182/blood-2017-02-770214
• CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells

  Yan Li, Long Gao, Brandon Hadland, Kai Tan and Nancy A. Speck

  Blood 2017 130:372-376; doi: https://doi.org/10.1182/blood-2017-03-776849
• NF-κB p50 (nfkb1) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia

  Timothy L. Chen, Minh Tran, Aparna Lakshmanan, Bonnie K. Harrington, Nikhil Gupta, Virginia M. Goettl, Amy M. Lehman, Stephen Trudeau, David M. Lucas, Amy J. Johnson, John C. Byrd and Erin Hertlein

  Blood 2017 130:376-379; doi: https://doi.org/10.1182/blood-2017-01-761130

BLOOD WORK

• Peripheral eosinophilia as the first manifestation of B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32)

  Dolores Gómez Toboso and Carmen Benet Campos

  Blood 2017 130:380; doi: https://doi.org/10.1182/blood-2016-12-754812
• Classical Hodgkin lymphoma and Castleman disease: a rare morphologic combination

  Shunyou Gong and Nobuko Hijiya

  Blood 2017 130:381; doi: https://doi.org/10.1182/blood-2017-05-782128

ERRATUM

• Curtis C, Mineyko A, Massicotte P, et al. Thrombophilia risk is not increased in children after perinatal stroke. Blood. 2017;129(20):2793-2800.

  Blood 2017 130:382; doi: https://doi.org/10.1182/blood-2017-06-789404

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

• Predicting transformation of follicular lymphoma

  Blood 2017 130:383; doi: https://doi.org/10.1182/blood-2017-05-786178