10 November 2025 (Monday) - Warm AIHA

I got that right…not that I will ever be deciding on the therapies, but it really helps if I know what the drugs are, what conditions they are for, and how they work.

Here’s the first reference, and here’s the second.

10 November 2025 (Monday) - BTLP-TACT Exercise

It’s pouring hard; the dog walk was a washout, and so with not a lot else on the agenda I thought I might as well do a BTLP-TACT exercise.
I was presented with one case – a thirty-eight year-old woman in theatre with a ruptured ectopic pregnancy needing six units of blood. She grouped as A Rh(D) Positive with a negative antibody screen. I selected six units of A Rh(D) Positive K Negative blood
I got it right.

6 November 2025 (Thursday) - BTLP-TACT Exercise

I suppose I should really do a BTLP-TACT exercise…  
I had one case – a seventy year old woman supposedly needing FFP for reversal of warfarin therapy.
Her ABO group was indeterminate (cell group A, no reaction in reverse group) but her Rh(D) group was negative.
The antibody screen was weakly positive in cells 1 and 2 so I performed antibody panels.
The IAT and enzyme panels were positive in cells 1, 2 and 3 corresponding with anti-D but not excluding anti-Cw.
Bearing in mind warfarin isn’t recommended for the reversal of warfarin therapy, I didn’t issue any.
I got it right this time…

5 November 2025 (Wednesday) - TACO-Related Fever

Here’s something to think about… back in the day transfusion trigger limits were a *lot* higher than they are these days. We’d give three or four units of blood where these days we’d only give one. And back in the day we were investigating quite a few alleged transfusion reactions which were characterized by post transfusion fevers. We’d do blood cultures… but nothing ever grew.

Were we seeing fevers related to transfusion associated circulatory overload?

4 November 2025 (Tuesday) - Fritsma Factor Newsletter

The Fritsma Factor newsletter appeared in my in-box this morning. As always it’s a rather useful source of information on matters haemostatic…


4 November 2025 (Tuesday) - Information Governance

I did my e-learning on information governance today. Governance… it’s a simple concept really. I have access to confidential information. I only discuss it with those who have a bona-fide reason to know what I know, and I keep my trap shut to everyone else. I make sure that no one could accidentally find out what I know… simple, really.