6 November 20117 (Monday) - Discriminatory ?

A thought-provoking article. Possibly not directly of relevance to me? Possibly it is? Do health care professional discriminate against those with sickle cell disease?


I don’t *think* so ..

4 November 2017 (Saturday) - Green Crystals


Another snippet from the Facebook Haematology Interest Group:

Had an interesting case involving green inclusions in neutrophils. My first thought was of the "green inclusions of death" I had read about in case studies and a couple of times here. They looked exactly like what I had seen in pictures.
However this was not the case in this patient. Here's some more information about the patient to see if you guys come to the same conclusion as the pathologist.
On the patients slide I had seen yeast forms and the green inclusions. The yeast forms were an important find but not relevant to the final diagnosis. Cultures are pending so it's not confirmed at this point. The patient had recently received a hip or knee replacement (don't exactly remember which but it's not relevant which one). The pathologist decided an iron stain would be helpful and it showed the inclusions did not contain iron. I've included a picture of the inclusions although it is not directly from this case. I don't have a picture of the iron stain but the inclusions stained a bright yellow


For all that I’ve mentioned the “green crystals of death” I’ve still to see any. Now there’s more than one sort of green crystal…

1 November 2017 (Wednesday) - Spreading by Transfusion

Can you catch Alzheimer’s disease? Fear has been growing that the illness might be capable of spreading via blood transfusions and surgical equipment, but it has been hard to find any evidence of this happening. Now a study has found that an Alzheimer’s protein can spread between mice that share a blood supply, causing brain degeneration…


The rest of the article can be found here. Thought provoking… back when it was found that HIV was spread by the transfusions of blood products I wondered just how many other things might be spread that way… here’s one such.

1 November 2017 (Wednesday) - Fire Training

I did my in-house fire training today… I mention it as I’m told it constitutes CPD…

1 November 2017 (Wednesday) - Thalassaemia ?


This image appeared on the Facebook Haematology Interest Group. Target cells, inclusion bodies, spherocytes… it’s *got* to be thalassaemia major, hasn’t it?



31 October 2017 (Tuesday) - Transfusion News Update

The nice people at Transfusion News sent their update today. All sorts of information for me:

U.S. Blood Supply at Risk—Blood Collection Agencies under Financial Stress

October 18, 2017
Blood collection centers in the United States have been providing a safe, reliable, and stable source of blood to hospitals for nearly a century. Unlike most countries, in the U.S., independent, non-profit suppliers compete with each other to supply hospitals and medical centers with blood, essentially treating it like a commodity in a free market.[Read More]

Trying to Decipher Relationship between Previously Pregnant Donors and RBC Transfusion-related Mortality

October 25, 2017
Although blood from previously pregnant female donors has been shown to be associated with transfusion-related acute lung injury (TRALI), the relationship between donor history of pregnancy and red blood cell (RBC) transfusion mortality has remained elusive. In order to better understand this relationship, researchers in the Netherlands retrospectively evaluated a cohort of 31,118 first-time transfusion [Read More]


Red Blood Cells Stored for More Than 35 Days are Safe

October 11, 2017
One of the major controversies in transfusion medicine has been whether red blood cell (RBC) storage lesions result in increased morbidity and mortality for transfusion recipients. Several randomized trials have evaluated this issue, but none had assessed RBCs stored for more than 35 days. A secondary analysis of the INFORM trial by Cook and colleagues [Read More]

30 October 2017 (Monday) - Transfusion Evidence Library update

The nice people at the Transfusion Evidence Library sent their update today. All sorts of information for me:

Top 10 new publications
Improving non-technical skills (teamwork) in post-partum haemorrhage: a grouped randomised trial
Letchworth PM, Duffy SP, et al. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2017
Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: a systematic review
Qassim A, Mol BW, et alThe Australian & New Zealand Journal of Obstetrics & Gynaecology 2017.
Continuous erythropoiesis receptor activator (CERA) for the anaemia of chronic kidney disease.
Saglimbene VM, Palmer SC, et al. Cochrane Database of Systematic Reviews. 2017.