29 November 2021 (Monday) - ASH Update

The American Society of Hematology sent their last month’s top five most read articles this morning, Being clinically-based they probably wouldn’t be my top five most read articles, but they were all useful reading.

TOP 5: This month's most-read articles
  1. Editor’s Corner: Joe’s Career Hacks
  2. New Prognostic Model Outperforms Established Predictive Models in MDS
  3. Pulling Back the Curtain: Caitlin Costello, MD
  4. Classical Hematology: A Specialty in Decline?
  5. No Difference in CNS Relapse Rates Between IT and IV Prophylaxis Routes in Non-Hodgkin Lymphomas


26 November 2021 (Friday) - Chediak Higashi Syndrome (possibly)


An interesting post on the Facebook “Hematology interest Group”. As always there was no indication whatsoever as to what the case was. Several people commented “Chediak Higashi Syndrome”. Was it? I don’t know, but it made me look up on something about which I’d not thought for some time.



25 November 2021 (THursday) - Transfusion Evidence Alert Update

The Transfusion Evidence Alert email arrived today. As always there was too much to take in at a single sitting, but it is all good stuff. And much of it relevant to what I do.


Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.Estcourt, L.J., et al. (2021). JAMA.PICO Summary available



Tranexamic acid for the prevention of postpartum hemorrhage in women undergoing cesarean delivery: an updated meta-analysis.Bellos, I., et al. (2021). American Journal of Obstetrics and Gynecology. [Record in progress]

Promoting awareness of donation-related iron depletion among high risk blood donors.France, J.L., et al. (2021). Transfusion. [Record in progress]

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial.Garbero, E., et al. (2021). Intensive Care Medicine.

Albumin in the management of hepatic encephalopathy: a systematic review and meta-analysis.Is, B., et al. (2021). Annals of Hepatology. [Record in progress]

Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low-to-middle income countries: a systematic review and meta-analysis.Ivain, P., et al. (2021). Journal of Perinatology: Official Journal of the California Perinatal Association.

Prothrombin Complex Concentrate for Trauma Induced Coagulopathy: A Systematic Review and Meta-Analysis.Kao, T.W., et al. (2021). Journal of Acute Medicine.

Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients.Mahmood, A., et al. (2021). Emergency Medicine Journal

A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial. McGuinness, S., et al. (2021). Vox Sanguinis. [Record in progress]