38895 – a sixty-nine year-old woman needing group and save. She grouped as A Rh(D) Positive with antibody screen positive in all three cells.I requested panels.The IAT panel was positive in cells 1, 3, 4, 6, 7, 9 and 10 - possible anti-Cw anti-Lu(a) anti-Fy(a) anti-Jk(a)The enzyme panel was positive in cells 1, 3, 4, 6, 7 - possible anti-Cw anti-Jk(a)So – this patient has anti-Fy(a) and anti-Jk(a) but anti-Cw cannot be excluded.17765 – a seventy-four year-old woman also needing group and save. She too grouped as A Rh(D) Positive with a negative antibody screen.
17 March 2024 (Sunday) - BTLP-TACT Exercise
14 March 2024 (Thursday) - Transfusion Evidence Alert Update
The Transfusion Evidence Library update
arrived today. Bearing World Kidney Day in mind, the focus was on renal
involvement:
Top article
Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT.
Jayne, D., et al. (2022). Health Technology Assessment.
PICO SUMMARY
Selected articles
Safety and efficacy of hypoxia-inducible factor-prolyl hydroxylase inhibitors vs. erythropoietin-stimulating agents in treating anemia in renal patients (with or without dialysis): a meta-analysis and systematic review.
Damarlapally, N., et al. (2023). Cureus.
Acute respiratory distress syndrome, acute kidney injury, and mortality after trauma are associated with increased circulation of syndecan-1, soluble thrombomodulin, and receptor for advanced glycation end products.
Dixon, A., et al. (2023). The Journal of Trauma and Acute Care Surgery.
Can trajectory nor-epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double-blinded randomized controlled trial.
El-Shaer, W., et al. (2022). International Journal of Urology.
Prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis of non-pharmacological interventions.
Hariri, G., et al. (2023). Critical Care.
Effect of blood transfusion post kidney transplantation on de novo human leukocytes antigen donor-specific antibody development and clinical outcomes in kidney transplant recipients: a systematic review and meta-analysis.
Kang, Z.Y., et al. (2023). Transplant Immunology.
Ferric citrate for the treatment of hyperphosphatemia and anemia in patients with chronic kidney disease: a meta-analysis of randomized clinical trials.
Li, L., et al. (2022). Renal Failure.
The effect of perioperative blood transfusion on survival after renal cell carcinoma nephrectomy: a systematic review and meta-analysis.
Liu, Y., et al. (2023). Frontiers in Oncology.
Efficacy of therapeutic apheresis for cryoglobulinemic vasculitis patients with renal involvement: a systematic review.
Miao, J., et al. (2023). Blood Purification.
Two phase 3 studies on ophthalmologic effects of roxadustat versus darbepoetin.
Sepah, Y.J., et al. (2022). Kidney International Reports.
13 March 2024 (Wednesday) - Hyperthyroidism
We had a patient today with a mild
neutropenia. The patient’s diagnosis was hyperthyroidism.
It
transpires that treatment of hyperthyroidism often causes a neutropenia
which resolves on cessation of treatment.
Something to bear in mind.
12 March 2024 (Tuesday) - IBMS Newsletter
12 March 2024 (Tuesday) - Oncology Central
The nice people at Oncology Central sent
their update today. Much (most) of it went over my head, but one or two
things stuck
10 March 2024 (Sunday) - BTLP-TACT Exercise
8 MArch 2024 (Friday) - NEQAS 2401 DM
Rbc Anisopoikilocytosis Nucleated red
cells Polychromasia Spherocytes Tear drop
cells |
Wbc Auer
rods Blast
cells Dohle
bodies Dysplastic
neutrophils Hypersegmented
neutrophils Left shifted
neutrophils Myelocytes |
Plts Grian
plts Grey
plts Megakaryocyte
fragments |
It was.
However I feel I must ask myself what I meant by “Grian plts” Bearing in mind nearly two months passed between my looking at the film and getting the results I have no recollection.