27 June 2019 (Thursday) - Transfusion Evidence Alert

The Transfusion Evidence Alert email came into my in-box this morning. As always there was far more that I could possibly take in in any one sitting, but one article made me think.

Older blood… does the age of transfused blood have any bearing on a patient’s clinical outcome. Obviously the stuff doesn’t last forever; it comes with an expiry date. But does giving older or fresher blood matter? Now it would seem that giving fresher blood to trauma cases reduces mortality.

Something to bear in mind? Especially as a trauma case requiring a *lot* of blood may well be seen as a way to shift the old stock?

26 June 2019 (Wednesday) - Lymph Nodes in CLL

The nice people at Lablogatory sent a case study today about lymph node involvement in CLL. You can read it by clicking here. Sometimes you forget that there is far more to a clinical condition than just the blood count…

26 June 2019 (Wednesday) - Sten Cell Evidence Alert

The nice people at the Stem Cell Evidence Alert sent their update today. As with much of the CPD I do it isn’t so much of direct useful relevance, but more of background interest. But it is that background interest which is perhaps where I need to concentrate. It’s so easy to get focussed on a very tiny aspect of a very specialised field and to forget that what I do on a day-to-day basis is only a tiny part of an enormous whole.

Selected new publications

Benefits and challenges with diagnosing chronic and late acute GvHD in children using the NIH consensus criteria
Cuvelier, G. D. E., Nemecek, E., et al., Blood 2019

Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)
Kansagra, A. J., Frey, N. V., et al. Bone marrow transplantation 2019

Response to novel drugs before and after Allogeneic Stem Cell Transplantation in Multiple Myeloma relapsing patients
Lopez-Corral, L., Velazquez, T. C., et al. Biology of blood and marrow transplantation 2019.

Reduced intensity allogeneic stem cell transplantation for younger patients with myelofibrosis
Mannina, D., Zabelina, T., et al. British journal of haematology 2019

Outcomes of allogeneic stem cell transplantation after inotuzumab ozogamicin treatment for relapsed or refractory acute lymphoblastic leukemia
Marks, D. I., Kebriaei, P., et al. Biology of blood and marrow transplantation 2019.
Free full text

Alternative donor transplantation for acute myeloid leukemia in patients aged >/=50 years: young HLA-matched unrelated or haploidentical Donor?
Perales, M. A., Tomlinson, B., et all. Haematologica 2019.
Free full text

Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia - A prospective international multicenter trial on behalf of the BFM-SG and the EBMT-PDWP
Pichler, H., Lawitschka, A., et al. American journal of hematology 2019.

Allogeneic stem cell transplantation using HLA-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the Acute Leukemia Working Party of the EBMT
Poire, X., Labopin, M., et al. Haematologica 2019.
Free full text

Impact of T-cell dose on the outcome of T-cell replete HLA matched allogeneic peripheral blood stem cell transplantation
Saad, A., Lamb, L., et al. Biology of blood and marrow transplantation 2019.

Article of the Month: June 2019 Allogeneic hematopoietic cell transplantation compared to chemotherapy consolidation in older acute myeloid leukemia (AML) patients 60-75 years in first complete remission (CR1): an alliance (A151509), SWOG, ECOG-ACRIN, and CIBMTR study Ustun, C., Le-Rademacher, J., et al.  Leukemia 2019 Free full text