21 April 2026 (Tuesday) - BTLP-TACT

Being at a bit of a loose end I thought I mihght do a BTLP-TACT exercise. I was pesented with one case – a seventy-eight year-old chap needing two units of cryo for factor VIII deficiency.
 
He grouped as O Rh(D) Positive with a negative antibody screen.
 
Is the cryo actually indicated in Factor VIII deficiency?  Well, https://pmc.ncbi.nlm.nih.gov/articles/PMC4627369/ says that it is rich in the stuff and has historically been used as a treatment for haemophilia A. But it potentially carries pathogens… The reference says that it is a second-line treatment.
I’m going to say that it *is* indicated and either way I will learn something.
 
So I issued two units and got the thumbs down. Apparently “Selection of any plasma components was inappropriate for this clinical condition”. One lives and learns…

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