APML… Promyelocytes might look vaguely “lymphy” at first glance but that’s because of the cytoplasm which (for the most part) lacks granules. But look at the nucleus. A lymphoid nucleus is generally sounder and more regular. The myeloid nucleus has lumps and bumps (albeit rounded).
I’m particularly prompted by the bit about “while morphology can strongly
suggest this diagnosis…” for many years that was all that could suggest any
diagnosis. It’s such a shame that cytogenetic and molecular testing are the
purview of specialist testing centres.
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