21 October 2025 (Tuesday) - Transfusion Evidence Library Update

The nice people at the Transfusion Evidence Library sent their update today. As ever there was a lot to take in, and a lot of it was very clinical. But that is a good thing; being able to advice on the efficacity of any proposed transfusions can only be a good thing.

I just hope that what I intend to be offered as help and advice to patient care is seen in that context.

ARTICLE OF THE MONTH

Ferritin-guided iron supplementation as an alternative or complement to prolonged blood donation intervals (FORTE): a double-blind, randomised, controlled trial.
Karregat, J.H.M., et al. (2025). The Lancet. Haematology.
PICO SUMMARY

 

 

TOP ARTICLES

Impact of thrombopoietin receptor agonists on platelet transfusion requirements in myelodysplastic syndromes: an updated systematic review and meta-analysis.
Aziz, N., et al. (2025). Clinical Lymphoma, Myeloma & Leukemia. [Record in progress].

Restrictive vs. liberal transfusion strategy in critically ill patients with acute brain injury: a systematic review and meta-analysis.
Boutrik, A., et al. (2025). Neurocritical Care. [Record in progress].

Meta-analysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning.
Cai, B., et al. (2025). Critical Reviews in Toxicology.

Evaluating economic and clinical impacts of anaemia management strategies: a systematic review of the evidence from the UK perspective.
Farabi, H., et al. (2025). EJHaem.

The effect of plasma donation frequency on total serum protein, immunoglobulin G and donor safety: a non-inferiority randomized controlled trial.
Haugen, M., et al. (2025). Vox Sanguinis. [Record in progress].

Viscoelastic testing in postpartum obstetric hemorrhage: a scoping review commissioned by the Patient-Centered Outcomes Research Institute (PCORI).
Janzen, C., et al. (2025). International Journal of Obstetric Anesthesia.

Clotting factor concentrates for preventing bleeding and bleeding-related complications in previously untreated or minimally treated children with hemophilia A or B.
Razmpoosh, E., et al. (2025). The Cochrane Database of Systematic Reviews.

Cord red blood cell transfusions for severe retinopathy in preterm neonates in Italy: a multicenter randomized controlled trial.
Teofili, L., et al. (2025). EClinicalMedicine.

Pilot-optimizing transfusion therapy in critically ill children with anemia: a pilot multicenter electronic health record-enabled randomized controlled trial on red blood cell transfusion in critically ill children.
Tucci, M., et al. (2025). Pediatric Critical Care Medicine.