13 October 2025 (Monday) - Unexplained Erythrocytosis

Well… presumably the chap is not unwell? The Hb of 18.4 isn’t especially high…
The JAK2 being negative pretty much rules out polycythaemia rubra vera (or polycythaemia Rupert Bear as I once heard it called).
Erythropoetin receptor mutations usually result in low levels of EPO so that is pretty much ruled out too.
EPO levels are typically higher in individuals with pulmonary diseases.
My gut feeling is that this would be a relative erythrocytosis until I saw the P50 was low.
 
This might be a haemoglobinopathy with a high affinity haemoglobin…  A haemoglobinopathy was the correct answer. I got it right... but this would be *very* obscure.
 
Here’s an article on erythrocytosis with several useful links.

No comments:

Post a Comment