17 September 2025 (Wednesday) - One or Two?


 

The nice people at the Transfusion Evidence Library sent their update today. As ever there were a load of articles, but one caught my eye…
 
Effect of single-unit transfusion in patients treated for haematological disease including acute leukemia: a multicenter randomized controlled clinical trial.
Chantepie, S.P., et al. (2023). Leukemia Research. [Link opens in Transfusion Evidence Library].
 
A comparison was made between people receiving two-unit blood transfusions as opposed to single unit transfusions. Back in the day it was common knowledge that the hazards of a single unit transfusion outweighed the benefits of that transfusion.
More recently this has been thrown out as being about as true as the flat earth theory…
However this trial has found that a single unit transfusion policy is not inferior to a double unit transfusion policy.
However, the single unit transfusion policy did not reduce the total number of units transfused per stay. Presumably people just have smaller transfusions more often.
Is that good or bad? Presumably this reduces TACO?

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