*Hypersegmented neutrophils*:
are neutrophils with more than the typical three to five nuclear lobes or
segments. Hypersegmentation is often associated with megaloblastic anaemia,
particularly due to vitamin B12 or folate deficiency.
It can also be seen in
myelodysplastic syndromes and other conditions affecting bone marrow function.
However this should not
be confused with neutrophils showing a “botryoid nucleus”; a botryoid nucleus
refers to a nucleus that has a grape-like clustering or lobulation with nine or
ten tight lobes. Hyper-hypersegmented (!)
While less common than
hypersegmentation, it is seen in heat stroke, influenza A, encephalitis, and
drug overdoses including cocaine and methamphetamine intoxication.
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