26 August 2025 (Tuesday) - BTLP-TACT Exercise

I’ve only done six BTLP-TACT exercises this month, and I’m getting snarky emails about not meeting performance targets. Mind you I did get one of those six wrong (allegedly!) so here goes…

 

I was presented with one case – an eighty-five year-old chap in A&E with a fractured femur needing two units of blood.

He grouped as A Rh(D) Positive with a negative antibody screen. I selected two units of A Rh(D) Positive blood

 

I got it right…

24 August 2025 (Sunday) - Plasma

The nice people at Blood Bytes and Beyond sent a little update on the uses of plasma today. You can read it by clicking here.

Liquid plasma – is that a new thing?

22 August 2025 (Friday) - UKAS Update

The nice people at UKAS sent their update today. You can read it by clicking here. There’s no denying that, being an old reactionary, I am very cynical about the entire concept of UKAS…

Which is exactly why I need to keep up with what they are up to. No matter what I think of them, I have to follow their instructions so it is as well that I keep abreast of what tey are saying.

22 August 2025 (Friday) - Under the Cover

One of the blood grouping analysers was being troublesome today. As luck would have it, a colleague used to work for the firm that makes the devices. With te cover off he spent ten minutes taking me through the intricacies of the machine’s insides.

I learned quite a bit, and as I always say a day when you learn nothing is a day wasted.

 

21 August 2025 (Thursday) - ASH Update

The nice people at ASH sent their update today. They’ve been sending them for some time, but there’s no denying that they go right over my head. But then, a lot of the journals do that. If I stick at them and read around and find out, then (just maybe) something might stick in my head.

After all, isn’t that what CPD is all about?

BLOOD COMMENTARIES       Cracking the POD24 code in follicular lymphoma     Florian Scherer   Blood August 2025, Vol.146, 899-900. doi: 10.1182/blood.2025029930     A burden too high for CAR T cells in CLL     Arnon P. Kater ; Maria Themeli   Blood August 2025, Vol.146, 901-902. doi: 10.1182/blood.2025029368     Protecting the epithelium and taming GVHD     Yishan Ye; Mohamad Mohty   Blood August 2025, Vol.146, 903-905. doi: 10.1182/blood.2025029271     The landscape of disease: mapping aplastic anemia     Patrick M. Brunner   Blood August 2025, Vol.146, 905-906. doi: 10.1182/blood.2025029791     Deep dive into shallow myeloma cell pool     Mehmet K. Samur   Blood August 2025, Vol.146, 906-907. doi: 10.1182/blood.2025029778     CALR-ifying ATF6/BCL-xL activation by type 2 CALR mutations     Fan He ; Stephen T. Oh   Blood August 2025, Vol.146, 907-908. doi: 10.1182/blood.2025029864     When TNFα is out, IFN-γ drives anemia of inflammation     Laura Silvestri   Blood August 2025, Vol.146, 908-910. doi: 10.1182/blood.2025030006     Checkpoint-primed allo-HCT in HL: cure gains, risk remains     Paul J. Bröckelmann; Bastian von Tresckow   Blood August 2025, Vol.146, 911-912. doi: 10.1182/blood.2025029908

PLENARY PAPER       Combined PET and ctDNA response as a predictor of POD24 for follicular lymphoma after first-line induction treatment     Alexis Claudel; Anne-Ségolène Cottereau; Emmanuel Bachy; Emmanuel Itti ; Pierre Feugier; Cedric Rossi; Francois Lemonnier; Vincent Camus; Nicolas Daguindau ; Guillaume Cartron; Emmanuelle Nicolas-Virelizier; Diana-Laure Mboumba; Christophe Cardoso; Côme Bommier; Benoit Tessoulin; Christophe Fruchart; Adrien Gilbert; Eric Durot; Emmanuel Fleck; Gian Matteo Pica; Hacene Zerazhi; Stephanie Guidez; Morgane Cheminant; Clementine Sarkozy; Luc Xerri; Laetitia Vercellino; Nesrine Trabelsi; Lucie Gomes; Cedric Portugues; Pierre-Julien Viailly; Marie-Hélène Delfau-Larue; Franck Morschhauser   Blood August 2025, Vol.146, 913-925. doi: 10.1182/blood.2024027727

PERSPECTIVE       Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies     Gerard Socie   Blood August 2025, Vol.146, 926-937. doi: 10.1182/blood.2025028617

CLINICAL TRIALS AND OBSERVATIONS       ZUMA-8: a phase 1 study of brexucabtagene autoleucel in patients with relapsed/refractory chronic lymphocytic leukemia     Matthew S. Davids; Saad S. Kenderian; Ian Flinn; Brian T. Hill; Michael Maris; Paolo Ghia; Michael Byrne ; Nancy L. Bartlett; John M. Pagel; Yan Zheng; Justyna Kanska; Wangshu Zhang ; Enrique Granados; Javier Pinilla-Ibarz   Blood August 2025, Vol.146, 938-943. doi: 10.1182/blood.2024027460     Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT     Eduard Schulz; Lauren M. Curtis; Noa G. Holtzman; Seth M. Steinberg; Kaska Wloka ; Alen Ostojic; Alain Mina; Najla El Jurdi; Filip Pirsl; Ashley Carpenter ; Mahshid Golagha; Arlene Sirajuddin; Theo Heller; Brian C. Shaffer; Frances T. Hakim ; Jeffrey S. Rubin; Ronald E. Gress; Steven Z. Pavletic   Blood August 2025, Vol.146, 944-950. doi: 10.1182/blood.2024028303

IMMUNOBIOLOGY AND IMMUNOTHERAPY       Imaging mass cytometry reveals the order of events in the pathogenesis of immune-mediated aplastic anemia     Emma S. Pool; Sietse J. Luk; Marieke E. Ijsselsteijn; Vincent van Unen; Noel F. C. C. de Miranda; J. H. Frederik Falkenburg; Frits Koning; Mirjam H. M. Heemskerk; Jennifer M.-L. Tjon   Blood August 2025, Vol.146, 951-963. doi: 10.1182/blood.2025028723

LYMPHOID NEOPLASIA       Ultrasensitive detection of circulating multiple myeloma cells by next-generation flow after immunomagnetic enrichment     Marta Lasa; Carmen Gonzalez; Laura Notarfranchi; Anastasiia Zherniakova ; Diego Alignani; Leire Burgos; Maria Jose Calasanz; Paula Rodriguez-Otero; Jose J. Perez ; Clara Gomez; Veronica Gonzalez de la Calle; Felipe de Arriba; Luis Palomera; Miguel Angel Alvarez Rivas; Esther Clavero; Enrique M. Ocio; Ana Pilar Gonzalez-Rodriguez; Sunil Lakhwani ; Angela Ibañez; Albert Oriol; Anna Sureda; Laura Rosiñol; Christiane Siewert; Alberto Orfao; Juan-Jose Lahuerta; Joan Blade; Maria-Victoria Mateos ; Jesus F. San-Miguel; Maria-Teresa Cedena; Joaquin Martinez-Lopez; Noemi Puig; Bruno Paiva; on behalf of the PETHEMA/GEM cooperative group   Blood August 2025, Vol.146, 964-970. doi: 10.1182/blood.2025029234

MYELOID NEOPLASIA       Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms     Nicole S. Arellano; William L. Heaton ; Mirielle C. Nauman; Abigail E. Runnels; Jacky Gomez-Villa; Daniele Vanni; Melissa Gaviria; Maihi Fujita; Nathan M. Krah; Michele Ciboddo; Saveg Yadav; Callie T. Brown; Parker D. Bowden; Amy K. Chen; Christopher Henning; Silvia Catricalà ; Ilaria Carola Casetti; Oscar Borsani; Elisa Rumi; Daniela Pietra; Isabelle Plo ; Caroline Marty; Marco Marchetti; Ami B. Patel; Caner Saygin; Shannon E. Elf   Blood August 2025, Vol.146, 971-983. doi: 10.1182/blood.2024026940

RED CELLS, IRON, AND ERYTHROPOIESIS       TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation     Amaliris Guerra; Vania Lo Presti; Ding-Wen Chen; Ana Catarina Martins; Ariel Rivera; Nolan Hamilton; Pankja Sharma; Yelena Z. Ginzburg; Carlo Castruccio Castracani; Carla Casu; Ritama Gupta; Raffaella Gozzelino; Edward M. Behrens ; Laura F. Bennett; Robert F. Paulson; Peter Kurre; Stefano Rivella   Blood August 2025, Vol.146, 984-997. doi: 10.1182/blood.2025029352

THROMBOSIS AND HEMOSTASIS       The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice     Weiqing Jing; Jocelyn A. Schroeder; Saurabh Kumar; Juan Chen; Yuanhua Cai; Lynn M. Malec; Alexander L. Dent; Weiguo Cui; Qizhen Shi   Blood August 2025, Vol.146, 998-1010. doi: 10.1182/blood.2025029470

TRANSPLANTATION       Outcomes of allogeneic HCT in Hodgkin lymphoma in the era of checkpoint inhibitors: a joint CIBMTR and EBMT analysis     Miguel-Angel Perales; Farrukh T. Awan; Ariane Boumendil; Jinalben Patel; Luca Castagna; Emanuele Angelucci; Herve Finel; Alexander Kulagin; Bertram Glass; Paolo Corradini; Alex F. Herrera; Didier Blaise; Mohamed A. Kharfan-Dabaja ; Khalid Halahleh; Sairah Ahmed; Carmen Martínez; Sebastian Giebel; Silvia Montoto ; Richard J. Jones; Nausheen Ahmed; Ryan C. Lynch; Marcos J. De Lima; Mazyar Shadman ; Craig S. Sauter; Kwang W. Ahn; Mehdi Hamadani; Ali Bazarbachi; Anna Sureda   Blood August 2025, Vol.146, 1011-1029. doi: 10.1182/blood.2024027197

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS       Allo-HCT in Hodgkin lymphoma after CPI       Blood August 2025, Vol.146, 1030. doi: 10.1182/blood.2025030720