I looked at the NEQAS 2203PA films on 18 August
2205 BF1
|
I saw:
Blast cells Nucleated red cells Plasma Cells Neutrophilia Myelocytes Hypochromia
?? CML
|
Consensus View
Nucleated RBCs Blast Cells Plasma Cells
Myelocytes Neutrophilia Left Shift Abnormal/Suspect Lymphocytes Lymphocytosis Reactive/Plasmacytoid Lymphocytes Polychromatic Cells |
“This film was from a patient know to have multiple myeloma (plasma cell myeloma), with progressive disease.
In addition to the plasma cell population, there was a leucoerythroblastic blood film with marked neutrophilia with toxic granulation. This is likely to be a neutrophilic leukaemoid reaction to myeloma, which has been shown in some patients to be due to secretion of granulocyte colony-stimulating factor by the neoplastic cells. It was reasonable to suspect sepsis but it is useful to know that a leukaemoid reaction in myeloma/plasma cell leukaemia can simulate infection or chronic neutrophilic leukaemia”.
Well…. I thought this was CML… clearly an understandable mistake and I’ve learned something.
2205 BF2
|
I saw:
2205 BF2
Blast cells Monocytosis Neutrophilia with agranular/dysplastic neutrophils Myelocytes Nucleated red cells Thrombocytopenia
?? CMML
|
Consensus View
Blast Cells Thrombocytopenia Monocytosis Myelocytes Nucleated RBCs Neutrophilia Promyelocytes Promonocytes Left Shift Hypogranular/Agranular Neutrophils |
“A total of 225 participants favoured a diagnosis of CMML”
I’ll take that…
No comments:
Post a Comment