16 Feruary 2021 (Tuesday) - Stem Cell Evidence Alert Update


The nice people at the Stem Cell Evidence Alert sent their update today. Much of it went over my head, but there were one or two snippets in there…


Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial. 
Fuchs, E.J., et al. (2021) Blood [record in progress].


Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study
Peters, C., et al. (2020) Journal of clinical oncology
Clinical Commentary: implications for practice and future work


Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma.
Baertsch, M. A., et al. (2021) Blood Cancer Journal 11(1):1.

Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia.
Craddock, C., et al. (2021) Journal of Clinical Oncology [record in progress].

Carfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) as induction therapy for transplant-eligible, newly diagnosed multiple myeloma patients (Myeloma XI+): Interim analysis of an open-label randomised controlled trial.
Jackson, G. H., et al. (2021) PLoS Medicine 18(1):e1003454.

Lenalidomide maintenance after autologous haematopoietic stem-cell transplantation in mantle cell lymphoma: results of a Fondazione Italiana Linfomi (FIL) multicentre, randomised, phase 3 trial.
Ladetto, M., et al. (2021) The Lancet. Haematology 2021;8(1):e34-e44.

Randomized phase II trial of extracorporeal phototherapy and steroids vs. steroids alone for newly diagnosed acute GVHD.
Mehta, R.S., et al (2021) Bone marrow transplantation [record in progress]

Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome
Myllymäki, M., et al. (2020) Blood 136(26):3070-3081.

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study.
Sharma, A., et al. (2021) The Lancet. Haematology [record in progress].

Autologous stem cell transplantation versus bortezomib for the first line treatment of systemic light chain amyloidosis in the UK.
Sharpley, F.A., et al (2021) European Journal of Haematology [record in progress]

Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins, B., et al (2021) Journal of Clinical Oncology [record in progress].


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