21 January 2021 (Thursday) - Transfusion News Update


The nice people at Transfusion News sent their update today. D-genotyping, more about the use of convalescent plasma (there’s a lot of contradictory stuff being said about this)… all good stuff.

RHD Genotyping in Transfusion Practice Could Identify Novel RHD Alleles and Conserve D-negative Blood

January 20, 2021
Partial D phenotypes (with altered D epitopes) and weak D phenotypes (with a reduced number of D antigens present on RBCs) are difficult to distinguish based on serology alone. Thus, genotyping the RHD locus is recommended to limit the risk of alloimmunization and to avoid unnecessary use of RhIG and D- blood. [Read More]


Early Convalescent Plasma Therapy Helps Prevent Severe COVID-19

January 12, 2021
COVID-19 convalescent plasma administered late in the course of disease has not shown clear benefits, but some studies suggest that early transfusion may be efficacious. In order to determine if convalescent plasma administered soon after infection may help to prevent severe disease in older patients, researchers in Argentina randomized 160 patients aged 65 or older to receive either convalescent plasma (N=80) or placebo (N=80) within 72 hours of symptom onset. [Read More]


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