9 March 2018 (Friday) - Smear Cells

Here’s an interesting article: “Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia

Here in the UK we call then “smear cells”. And bearing in mind they are smeared broken cells, opinion has always been not to count them. However a retrospective review has been carried out.

“Between 1994 and 2002, 108 patients were enrolled onto the study and had archived blood smears available for review; 80% of patients had Rai stage 0 or I disease. The median smudge cell percentage was 28% (range, 1% to 75%). The percentage of smudge cells was lower in CD38+ versus CD38– patients (P = .019) and in Zap70-positive versus Zap70-negative patients (P = .028). Smudge cell percentage as a continuous variable was associated with prolonged survival (P = .042).”

“The 10-year survival rate was 50% for patients with 30% or less smudge cells compared with 80% for patients with more than 30% of smudge cells (P = .015). In multivariate analysis, the percentage of smudge cells was an independent predictor of overall survival.”

The practical upshot of all of this is that “Percentage of smudge cells on blood smear is readily available and an independent factor predicting overall survival in CLL.

I might jut have a word with the bosses at work. This is something we could do.

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