10 January 2017 (Tuesday) - Transfusion News email

KEL-Antigen Modulation is Important for Anti-KEL Immunoprophylaxis

January 5, 2017
Rh immunoglobulin therapy has been used for more than 60 years to prevent alloimmunization in Rh-negative pregnant women carrying an Rh-positive fetus. The exact mechanism, however, of prevention remains unknown. Using a mouse model, Liu et al investigated the mechanism of alloimmunization to the KEL antigen on red blood cells (RBCs) and described the first ...

Red Cells Stored Longer than Five Weeks May be Harmful

December 21, 2016
AABB’s clinical practice guidelines recently stated that transfusion of fresh red blood cells (RBCs) compared to standard issue RBCs have similar clinical outcomes, but also stated there are questions about the last week of storage. RBCs may be stored up to 6 weeks (42 days). Rapido and colleagues transfused 60 healthy adult volunteers with one ...

Screening for Babesia microti Decreases the Risk of Transfusion-Transmitted Infections

December 14, 2016
Babesia microti is a tick-borne pathogen responsible for babesiosis—a malaria-like hemolytic disease. Currently, there is not a licensed screening test for B. microti, which is responsible for the most fatalities due to parasitic transfusion-transmitted infections. As reported in The New England Journal of Medicine, researchers at the Red Cross recently investigated a screening protocol for...

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