29 August 2014 - Anti- Chido Antibodies



A patient was admitted for blood transfusion who was known to have anti-Chido antibodies. The patient’s records said:


Anti-Chido present.

Conduct antibody panel and crossmatching as follows: Pool together plasma from three male group O patients (antibody screens negative).
Add equal volumes of this pooled plasma to your patient plasma in a 1 to 1 ratio. Use this plasma mix to perform your antibody panel and crossmatch.

If red cell products have been transfused since the last NHSBT testing, refer samples to NHSBT to determine if further allo antibodies have been produced.

If no transfusion has occured (weak reactions may still be obtained) or, the antibody screen is negative, it is safe to issue red cells that are least reactive.

Select group O, rr, K- red cells.




Seemed odd to me… on further reading the Chido antigen is part of the complement cascade, so pooling with normal plasma will mop up any anti-Chido and so any reaction found in this pooled plasma will be “genuine” blood group antibodies.

There is quite a bit on the subject available on-line; especially at:



Mind you I have no idea why the pool has to be from male patients; nor does anyone else that I ask…

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