27 May 2024 (Monday) - Seriously?

Well… here’s a weird one. Leaving aside the fact that no one has performed an osmotic fragility in the last thirty years I’ve never seen a curve showing greater resistance to lysis. The curve is shifted to the right. Bearing in mind that HS, HE and AIHA would give lower resistance to lysis (curve shifted to the left) the correct answer must be sickle cell anaemia. Which thinking about it would seem to be right (which it was).

But who on earth would do an osmotic fragility when a simple blood film would point you in the right direction?


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