23 May 2024 (Thursday) - Transfusion Evidence Alert

Every month when the Transfusion Evidence Alert comes in I say about what wonderful stuff tranexamic acid is… I gets mentions this time as well…

ARTICLE OF THE MONTH

Association between tranexamic acid and decreased periprosthetic joint infection risk in patients undergoing total hip and knee arthroplasty: a systematic review and meta-analysis of over 2 million patients.
Elmenawi, K.A., et al. (2024). The Journal of Arthroplasty. [Record in progress].
PICO Summary available

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TOP ARTICLES

A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: the BEST collaborative study.
Apelseth, T.O., et al. (2024). Transfusion. [Record in progress].

The statistical fragility of tranexamic acid use in the orthopaedic surgery literature: a systematic review of randomized controlled trials.
Brown, A.N., et al. (2024). The Journal of the American Academy of Orthopaedic Surgeons.

Blood donation for iron removal in individuals with HFE mutations: study of efficacy and safety and short review on hemochromatosis and blood donation.
Infanti, L., et al. (2024). Frontiers in Medicine.

Defining ultra-massive transfusion through a systematic review.
Meyer, C.H., et al. (2024). American Journal of Surgery.

Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis.
Mustafa, H.J., et al. (2024). American Journal of Obstetrics and Gynecology. [Record in progress].

Fewer severe infections with tranexamic acid in patients with hematologic malignancies.
Poston, J.N., et al. (2024). Research and Practice in Thrombosis and Haemostasis.

Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease.
Saraf, S.L., et al. (2024). Blood Advances. [Record in progress].

Tranexamic acid versus placebo in individuals with intracerebral haemorrhage treated within 2 h of symptom onset (STOP-MSU): an international, double-blind, randomised, phase 2 trial.
Yassi, N., et al. (2024). The Lancet. Neurology.

Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis.
Zhang, Y., et al. (2024). Systematic Reviews.


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