13 May 2022 (Friday) - Transfusion News Update

The nice people at “Transfusion News” sent their update today:


Target Trial Emulation Using Real World Data Suggest Older RBCs May Increase Mortality

May 11, 2022Data from many randomized clinical trials (RCTs) have not found an impact of storage time of red blood cells on patient outcomes. A newly published paper, however, questions the outcome and validity of these RCTs noting inherent clinical, methodological, and statistical problems. Namely, study arms with substantially different ages of fresh and old cells are logistically difficult due to the nature of stocking blood, and many of the RCTs were not powered to detect small but possibly meaningful effects of storage time. [Read More]


Tranexamic Acid in Noncardiac Surgeries

May 3, 2022Large randomized clinical trials have shown that tranexamic acid safely reduces bleeding in patients undergoing cardiac surgery or cesarean sections, and evidence from orthopedic surgeries suggest that tranexamic acid is also safe and effective. Limited data, however, exist for patients undergoing nonorthopedic or noncardiac surgeries. [Read More]

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