I
read an interesting article today. You can read it at:
“Percentage of smudge cells in CLL patients
has recently been reported as a novel prognostic factor….. Ninety adults with
CLL were enrolled. Smudge cells percentage was calculated by microscopic evaluation
of blood smears. Testing of CD38 expression was done by immunophenotyping and
detection of…
Results: Lower smear
cells percentage (<30%) was significantly correlated with age,
lymphadenopathy, organomegaly and advanced staging. It was also associated with
high TLC, low hemoglobin and platelets count and high absolute and atypical
lymphocytic count.
Correlation studies
with other prognostic factors revealed an association between low smear cells
percentage and CD38 expression, short LDT, P53 and ATM deletions. Logistic
regression analysis was also done to provide complementary prognostic information
identifying the significant independent factors that predict low smear cell
percentage.
Conclusion: low
percentage of smudge cells (<30%) could be considered as an adverse
prognostic predictor being associated with high risk markers in CLL.”
Interesting…
I’m hearing this more and more. I was always told the smear/smudge cells were
dead things do be ignored. Maybe we should be counting them?
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